Microbial-induced Synthesis of nano NiFe LDH for High-efficiency Oxygen Evolution.

NiFe layered double hydroxide (LDH) currently are the most efficient catalysts for the oxygen evolution reaction (OER) in alkaline environments. However, the development of high-performance low cost OER electrocatalysts using straightforward strategies remains a significant challenge. In this study, we describe an innovative microbial mineralization-based method for in situ-induced preparation of NiFe LDH nanosheets loaded on nickel foam and demonstrate that this material serves as an efficient oxygen evolution electrocatalyst.

Healthcare providers' (HCPs) perspectives in initiating discussion on mammogram screening, and their perceived barriers and enablers to screening in women-A qualitative study.

Background: Breast cancer is the most common cancer in women, and mammogram screening can reduce breast cancer mortality. Healthcare providers' perspectives can have an impact on encouraging females to attend mammogram screening.

Objective: To understand healthcare providers' (HCPs) perspectives in initiating discussion on mammogram screening, and their perceived barriers and enablers to screening in women.

Photoinduced electron transfer enables cytochrome P450 enzyme-catalyzed reaction cycling.

Cytochrome P450 enzymes (CYPs), the members of the largest superfamily of enzymes in plant kingdom, catalyze a variety of functional group transformations involved in metabolite biosynthesis, end-product derivatization, and exogeneous molecule detoxification. Nevertheless, CYPs' functional characterization and practically industrial application have been largely encumbered by their critical dependency on the reducing equivalent for the catalytic cycling, driven by the tedious electron relay mediated by CYP reductase (CPR). Here, we report a photoinduced electron transfer system that initiates and sustains the CYP-catalyzed reaction cycling.

The impact of perceived stress on the prognosis in patients undergoing percutaneous coronary intervention.

Objective: To assess the impact of perceived stress levels in patients undergoing percutaneous coronary intervention (PCI) on the occurrence of major adverse cardiovascular events (MACEs) within a 6-month follow-up period postprocedure.

Methods: A cohort of 339 hospitalized patients with coronary heart disease undergoing initial PCI was prospectively enrolled in the Department of Cardiology at two branches of Zhongda Hospital Affiliated to Southeast University between January 2022 and July 2022. Baseline data including demographic and clinical characteristics, along with the Chinese Perceived Stress Scale (CPSS), were collected.

Improved bioavailability of polydatin and its protective effect against cisplatin induced nephrotoxicity through self-assembled fucoidan and carboxymethyl chitosan delivery system.

Cisplatin induced acute kidney injury (AKI) is clinically prevalent, with a complex pathogenesis and a lack of effective therapeutic drugs. Polydatin (Po) has excellent biological activity, but its low solubility and bioavailability limit its application. In this study, fucoidan (Fu) and carboxymethyl chitosan (Cs) self-assembled into nanoparticles through electrostatic interactions/hydrogen bonding and loaded Po (Fu/Cs Po NPs).

HER2-Targeted Affibody Molecule 99mTc-ABH2 for Imaging HER2 Expression in Breast Cancer.

Purpose: Accuracy in in vivo assessment of human epidermal growth factor receptor type 2 (HER2) status is crucial for predicting the response to HER2-targeted therapies in breast cancer. This study assessed the safety, feasibility, and diagnostic accuracy of 99mTc-ABH2, a reengineered affibody molecule with radionuclide labeling, for HER2 expression in breast cancer using SPECT/CT imaging, compared with 18F-FDG PET/CT.

Patients And Methods: Thirty-six patients suspected of primary breast cancer were enrolled in this prospective, single-center study from March to July in 2023.

Generalized cell phenotyping for spatial proteomics with language-informed vision models.

We present a novel approach to cell phenotyping for spatial proteomics that addresses the challenge of generalization across diverse datasets with varying marker panels. Our approach utilizes a transformer with channel-wise attention to create a language-informed vision model; this model's semantic understanding of the underlying marker panel enables it to learn from and adapt to heterogeneous datasets. Leveraging a curated, diverse dataset with cell type labels spanning the literature and the NIH Human BioMolecular Atlas Program (HuBMAP) consortium, our model demonstrates robust performance across various cell types, tissues, and imaging modalities.

Facilitating Oriented Electron Transfer from Cu to MoC MXene for Weakened Mo─H Bond Toward Enhanced Photocatalytic H Generation.

MoC MXene (MoCT) is recognized as an excellent cocatalyst due to unique physicochemical properties and platinum-like d-band of Mo active sites. However, Mo sites of MoCT with high-density empty d-orbitals exhibit strong Mo─H bonds during photocatalytic hydrogen evolution, leading to easy adsorption of hydrogen ions from solution and unfavorable desorption of H from Mo sites. To weaken the Mo─H bond, a strategy of oriented electron transfer from Cu to MoCT to increase the antibonding orbital occupancy of Mo─H hybrid orbitals is implemented by introducing Cu into MoCT interlayers to form Cu-MoCT.

Potassium-Based Solid Sorbents for CO Adsorption: Key Role of Interconnected Pores.

Industrial CO emissions contribute to pollution and greenhouse effects, highlighting the importance of carbon capture. Potassium carbonate (KCO) is an effective CO absorbent, yet its liquid-phase absorption faces issues like diffusion resistance and corrosion risks. In this work, the solid adsorbents were developed with KCO immobilized on the selected porous supports.

Residential blue space, cognitive function, and the role of air pollution in middle-aged and older adults: A cross-sectional study based on UK biobank.

This study examines the relationship between residential exposure to blue spaces (e.g., rivers, lakes, and seas) and cognitive function in middle-aged and older adults in the United Kingdom, with a specific focus on the mediating effects of air pollution, particularly nitrogen dioxide (NO₂) and fine particulate matter (PM).

The Value of PHQ-9 and GAD-7 for Screening Emotional Disorders in IBS-D and the Specificity of the Gut Flora Associated with Emotional Comorbidity: Preliminary Findings.

Background: To identify irritable bowel syndrome with diarrhea (IBS-D) combined with anxiety and/or depression through a psychological screening tool and to further explore the relationships between patients with comorbidities and gut microbiota.

Methods: The GAD-7, SAS, PHQ-9 and SDS were administered to evaluate anxiety and depression. Faeces were subsequently collected from 44 patients with emotional disorders (IBS-EDs), 22 patients without emotional disorders (IBS-nEDs) and 18 healthy controls (HCs) via 16S rRNA sequencing, depending on the participants' wishes.

In-situ construction and exciting photocatalytic performance of broad-spectrum responsive BiO/BiOCO heterojunctions in tetracycline degradation.

The wastewater polluted by antibiotics is very harmful and dangerous since these contaminants are poisonous and cannot occur by self-degradation. Research has verified that photocatalytic degradation is an effective strategy for addressing this issue; thus, developing a promising photocatalyst is indispensable. In this work, BiO/BiOCO nanosheet heterojunctions were constructed with an in-situ growth method, and their structure-photocatalytic performance relationships in degrading tetracycline (TC) were elucidated in detail.

Unveiling Noncentrosymmetric Pyridine Carboxylates from Centrosymmetric Templates through Motif Configuration Modulation in Zero-Dimensional System.

Developing approaches to induce noncentrosymmetric (NCS) frameworks through atomic-scale structural optimizations is crucial due to the growing need for new ultraviolet (UV) nonlinear optical (NLO) materials. Herein, the first two new NCS pyridine carboxylates, ZnBr(CHFNO) () and Cd(CHFNO)(HO) (), were successfully synthesized using centrosymmetric (CS) templates and rational structural reconstructions induced by different ionic radius. Both compounds crystallize in the orthorhombic system and feature metal-centered zero-dimensional (0D) isolated clusters.

Methotrexate inhibits glucocorticoids-induced osteoclastogenesis via activating IFN-γR/STAT1 pathway in the treatment of rheumatoid arthritis.

Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by the synovitis and bone erosion. The combination therapy of glucocorticoids (GCs) and methotrexate (MTX) is recommended in early RA management, although the precise underlying mechanism of action remains unclear. This study is aimed to clarify the mechanism of MTX in combined with GC in treating RA.

Transarterial Infusion Chemotherapy and Embolization for Patients With Unresectable Advanced Cancer of Stomach or Gastroesophageal Junction: A Retrospective Study.

Purpose: The feasibility of transarterial infusion chemotherapy and embolization (TAICE) in the treatment of advanced gastric cancer remains unclear. This study explored the value of TAICE in patients with unresectable locally advanced or metastatic cancer of stomach or gastroesophageal junction (GEJ).

Methods: Patients with unresectable gastric cancer who received TAICE for tumor hemorrhage cessation were enrolled in this retrospective study.

Breaking Symmetry for SHG Response: Lanthanide Acetate Crystals via Water Molecule Regulation Strategy.

In the field of nonlinear optical (NLO) materials research, the design and synthesis of novel materials are crucial for advancing modern scientific and technological development. This study employs an innovative coordination strategy, building upon the existing structure of [Ln(CHCOO)(HO)]·4HO (Ln = Tb, Sm), to successfully synthesize a series of acetate rare-earth metal compounds [Ln(CHCOO)(HO)] [Ln = Tb(), Er(), Y()] by regulating the number of water molecules. This approach achieved a structural transition from centrosymmetric (CS) to noncentrosymmetric (NCS), endowing these compounds with significant nonlinear optical responses.

Interaction between intestinal mycobiota and microbiota shapes lung inflammation.

Gut microbiota is an intricate microbial community containing bacteria, fungi, viruses, archaea, and protozoa, and each of them contributes to diverse aspects of host health. Nevertheless, the influence of interaction among gut microbiota on host health remains uncovered. Here, we showed that the interaction between intestinal fungi and bacteria shaped lung inflammation during infection.

Tetraphenylethene-Based Ni-Pyrazolate Metal-Organic Framework for Photoredox/Nickel Dual Catalysis of C-S Cross-Coupling.

As a prototypical aggregation-induced emission luminogen (AIEgen), the tetraphenylethene (TPE) moiety has been judiciously modified as organic linkers for constructing various functional metal-organic frameworks (MOFs). However, these AIEgen-based MOFs have rarely received research attention in photocatalytic applications due to their limited stability in harsh reaction conditions. In this work, we report a robust Ni-pyrazolate-based MOF (denoted as TPE4Pz-Ni) under the guidance of reticular chemistry, which is assembled by an AIE-active tetratopic linker of 1,1,2,2-tetrakis(4-(1-pyrazol-4-yl)phenyl)ethane (H-TPE4Pz) with a 12-connected Ni-cluster of [Ni(OH)(HO)Pz] (Pz = pyrazolate) in a (4,12)-connected -a topological network.

Platinum-induced nanolization and electron-deficient gold in platinum@gold cocatalyst for efficient photocatalytic hydrogen peroxide production.

Simultaneous optimization of the number and intensity of oxygen (O) adsorption on gold (Au) cocatalyst is highly required to greatly improve their interfacial hydrogen peroxide (HO)-production activity. However, it is a great challenge to realize the above effective modulation of Au by traditional photodeposition route. In this study, a platinum (Pt)-induced selective photodeposition method was designed to simultaneously regulate the particle size and electronic structure of Au cocatalyst for boosting the photocatalytic HO-production activity of bismuth vanadate (BiVO) via the selective deposition of Pt@Au core-shell cocatalyst.

ProT-Diff: A Modularized and Efficient Strategy for De Novo Generation of Antimicrobial Peptide Sequences by Integrating Protein Language and Diffusion Models.

Antimicrobial peptides (AMPs) are a promising solution for treating antibiotic-resistant pathogens. However, efficient generation of diverse AMPs without prior knowledge of peptide structures or sequence alignments remains a challenge. Here, ProT-Diff is introduced, a modularized deep generative approach that combines a pretrained protein language model with a diffusion model for the de novo generation of AMPs sequences.