Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.

Animals have evolved pH-sensing membrane receptors, such as G-protein-coupled receptor 4 (GPR4), to monitor pH changes related to their physiology and generate adaptive reactions. However, the evolutionary trajectory and structural mechanism of proton sensing by GPR4 remain unresolved. Here, we observed a positive correlation between the optimal pH of GPR4 activity and the blood pH range across different species.

Microplastics in China's surface water systems: Distribution, driving forces and ecological risk.

Comprehensively understanding the distribution, driving forces and ecological risk of microplastics (MPs) in China's surface water systems is crucial for future prevention and control of MPs pollution, particularly in the context of regional differences. Nevertheless, traditionally localized investigation and the limited MPs data availability hinder more comprehensive estimation of MPs pollution in surface water systems of China. This study presents a robust dataset, which consists of 14285 samples from 32 provincial districts, describing the MPs pollution characteristics using a data mining method combined with a machine learning model.

Spatiotemporal variations and the ecological risks of microplastics in the watersheds of China: Implying the impacts of the COVID-19 pandemic.

China is not only the first reported place of the COVID-19 pandemic but also is the biggest microplastic emitter in the world. Nevertheless, the impact of the COVID-19 pandemic on microplastic pollution in the watersheds of China remains poorly understood. To address this, the present study conducted a data mining and multivariate statistical analysis based on 8898 microplastic samples from 23 Chinese watershed systems before and during the COVID-19 pandemic.

Effects of algal organic matters on microporous ceramic emitters clogging in agricultural water distribution systems: Experiment and molecular simulation investigations.

The mechanism by which algal organic matter (AOM) affects the clogging of ceramic emitters remains unclear, which partially reduces the operational life of agricultural water distribution systems. This paper systematically investigated the clogging phenomenon of ceramic emitters under three different AOM concentrations. The results of irrigation tests revealed that the AOM significantly affects the degree of clogging of ceramic emitters, with higher AOM concentrations leading to faster flow reduction.

Nitroreductase-responsive nanoparticles for in situ fluorescence imaging and synergistic antibacterial therapy of bacterial keratitis.

As bacterial keratitis progresses rapidly, prompt intervention is necessary. Current diagnostic processes are time-consuming and invasive, leading to improper antibiotics for treatment. Therefore, innovative strategies for diagnosing and treating bacterial keratitis are urgently needed.

Realizing efficient broadband near-infrared emission and multimode photoluminescence switching coordination structure modulation in Sb-doped 0D organic metal chlorides.

Recently, organic Sb(III)-based metal halides have achieved significant results in the visible light region due to their efficient emission. However, realizing efficient broadband near-infrared (NIR) emission in such materials is a great challenge. Herein, we developed three different NIR emitters a coordination structure modulation strategy in Sb-doped zero-dimensional organic metal chlorides of (CHP)MnCl, (CHP)ZnCl, and (CHP)CdCl with tetrahedral structure.

Reduction of pathogenic bacteria from irrigation water through a copper-loaded porous ceramic emitter.

The increasing pathogenic bacteria threat in irrigation water has become a worldwide concern, prompting efforts to discover a new cost-effective method for pathogenic bacteria eradication, different than those currently in use. In this study, a novel copper-loaded porous ceramic emitter (CPCE) was developed via molded sintering method to kill bacteria from irrigation water. The material performance and hydraulic properties of CPCE are discussed herein, and the antibacterial effect against Escherichia coli (E.

Positive selection-driven fixation of a hominin-specific amino acid mutation related to dephosphorylation in IRF9.

The arms race between humans and pathogens drives the evolution of the human genome. It is thus expected that genes from the interferon-regulatory factors family (IRFs), a critical family for anti-viral immune response, should be undergoing episodes of positive selection. Herein, we tested this hypothesis and found multiple lines of evidence for positive selection on the amino acid site Val129 (NP_006075.

Realizing High-Efficiency Yellow Emission of Organic Antimony Halides via Rational Structural Design.

Zero-dimensional (0D) organic metal halides have captured extensive attention for their various structures and distinguished optical characteristics. However, achieving efficient emission through rational crystal structure design remains a great challenge, and how the crystal structure affects the photophysical properties of 0D metal halides is currently unclear. Herein, a rational crystal structure regulation strategy in 0D Sb(III)-based metal halides is proposed to realize near-unity photoluminescence quantum yield (PLQY).

Novel rare mutation in a conserved site of PTPRB causes human hypoplastic left heart syndrome.

Hypoplastic left heart syndrome (HLHS) is a rare but fatal birth defect in which the left side of the heart is underdeveloped. HLHS accounts for 2% to 4% of congenital heart anomalies. Whole genome sequencing (WGS) was conducted for a family trio consisting of a proband and his parents.

Global Scientific Research Landscape on Medical Informatics From 2011 to 2020: Bibliometric Analysis.

Background: With the emerging information and communication technology, the field of medical informatics has dramatically evolved in health care and medicine. Thus, it is crucial to explore the global scientific research landscape on medical informatics.

Objective: This study aims to present a visual form to clarify the overall scientific research trends of medical informatics in the past decade.

The de novo assembly of a European wild boar genome revealed unique patterns of chromosomal structural variations and segmental duplications.

The rapid progress of sequencing technology has greatly facilitated the de novo genome assembly of pig breeds. However, the assembly of the wild boar genome is still lacking, hampering our understanding of chromosomal and genomic evolution during domestication from wild boars into domestic pigs. Here, we sequenced and de novo assembled a European wild boar genome (ASM2165605v1) using the long-range information provided by 10× Linked-Reads sequencing.

Emitter clogging characteristics under reclaimed wastewater drip irrigation: a meta-analysis.

Background: Although reclaimed wastewater drip irrigation (RWDI) is an effective technology for alleviating agricultural crop water stress and protecting the environment, the reclaimed wastewater (RW) may cause emitter clogging. Discharge ratio variation (Dra) and coefficient of uniformity (CU) play a key role in exploring the clogging degree of the emitter. Therefore, a meta-analysis was conducted to identify optimal management methods with an acceptable Dra and CU under RWDI.

[Effects of nitrogen application level on photosynthate distribution of Korla fragrant pear trees].

Using C pulsed labeling technique, we examined the biomass and carbon accumulation of different organs as well as the distribution characteristics of C assimilate of 6-year-old Korla fragrant pear trees under three nitrogen application levels, ., 150, 300, and 450 kg N·hm (marked as N, N, and N, respectively). Results showed that the biomass, carbon accumulation, C fixation and leaf assimilation capacity of the whole pear tree increased while root to shoot ratio decreased with increasing nitrogen application.

Topical Capsaicin for the Treatment of Neuropathic Pain.

Background: Neuropathic pain (NP) is an egregious problem worldwide. Due to the side-effects of oral drugs, drugs delivered directly to the affected area of pain are preferred.

Objective: Capsaicin, a chemical compound isolated from chili peppers, is used as an analgesic in topical ointments and dermal patches to alleviate pain.

Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease.

Parkinson's disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia, and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset of Parkinson's disease. The exact pathogenesis of Parkinson's disease is quite complicated and the present anti-Parkinson's disease treatments appear to be clinically insufficient.

Comparative experiments of electrical conductivity from whey protein concentrates conventional film and nanofibril film.

We compared the electrical conductivity from two different aggregates of whey protein concentrates (WPC) film: conventional amorphous aggregation at natural pH (pH 6.5) and amyloid fibrils at a low pH (pH 2.0) far away from the isoelectric point.

Molecular digitization of a botanical garden: high-depth whole-genome sequencing of 689 vascular plant species from the Ruili Botanical Garden.

Background: Genome sequencing has been widely used in plant research to construct reference genomes and provide evolutionary insights. However, few plant species have had their whole genome sequenced, thus restraining the utility of these data. We collected 1,093 samples of vascular plant species growing in the Ruili Botanical Garden, located in southwest China.

Relationship between filtering bleb vascularization and surgical outcomes after trabeculectomy: an optical coherence tomography angiography study.

Purpose: To explore the relationship between the bleb vasculature and surgical outcome after trabeculectomy (TRAB) using optical coherence tomography angiography (OCT-A).

Methods: A prospective study was conducted, which included 26 eyes of 26 primary glaucoma patients in the final analysis. Thereinto, six patients underwent TRAB combined 5-FU and 12 patients received subconjunctival 5-FU injection postoperation.