Clinical features, risk factors, outcomes, and prediction model for intrahepatic and perihepatic abscess following hepatectomy for hepatocellular carcinoma.

Background: Intrahepatic and perihepatic abscess (IPHA) is a severe yet understudied complication that can occur after hepatectomy. This multicenter study aimed to elucidate the clinical features, risk factors, and outcomes of IPHA after hepatectomy for hepatocellular carcinoma (HCC), and to develop a novel prediction model for personalized risk assessment.

Methods: This was a multicenter cohort study of HCC patients who underwent curative-intent hepatectomy.

Controlled Release of Human Dental Pulp Stem Cell-Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis.

Temporomandibular joint osteoarthritis (TMJOA) is a painful inflammatory condition that limits mouth opening. Cell-derived exosomes, which have anti-inflammatory effects, are emerging as a treatment for TMJOA. Injection of dental pulp stem cells (DPSCs), which secrete exosomes, can moderate tissue damage in a rat model of TMJOA.

Efficacy of Self-Formulated Ergan Tang on Paroxysmal Atrial Fibrillation in Elderly Patients with Qi-Yin Deficiency: Impact on Inflammatory Marker Levels.

Background: The aim of this study is to assess the clinical efficacy of the self-formulated Ergan Tang on managing paroxysmal atrial fibrillation (AF) characterized by qi-yin deficiency among elderly patients.

Methods: A cohort of 40 elderly patients diagnosed with paroxysmal AF who spontaneously reverted to sinus rhythm were enrolled based on predetermined inclusion and exclusion criteria. These participants were randomly divided into two groups: self-formulated Ergan Tang group and amiodarone group.

pH-regulated CQDs@Eu/GMP ICP sensor array and its fingerprinting on 96-well plates: Toward point-of-use/specific identification and quantitation of six tetracyclines in animal farm wastewater, milks and milk-derivative products.

Herein, a "lab-on-an-AIE@Ln/ICP" sensor array was constructed by employing aggregation-induced emission carbon quantum dots (AIE-CQDs) as the guest and Eu/GMP ICP as the host. Based on the antenna effect (AE) and reductive photo-induced electron transfer (r-PET) between CQDs@Eu/GMP ICPs and tetracyclines (TCs), the as-constructed sensor produced satisfactorily dual-emitting fluorescence. By combining pH regulation with principal component analysis (PCA), the underlying fingerprinting patterns realized the specific identification and quantitation of six TCs in animal farm wastewater, milks and milk-derivative products.

circUBR5 promotes ribosome biogenesis and induces docetaxel resistance in triple-negative breast cancer cell lines via the miR-340-5p/CMTM6/c-MYC axis.

Objective: Docetaxel (DTX) represents an effective chemotherapeutic agent for treating triple-negative breast cancer (TNBC), but the efficacy is strongly limited by drug resistance. c-MYC-mediated ribosome biogenesis is considered a feasible strategy to confront chemoresistance in BC. We elucidated the impact of CMTM6 on TNBC DTX chemoresistance by governing c-MYC-mediated ribosome biogenesis, and its upstream ceRNA regulatory pathways.

High fluorescence quantum yield of methionine-doped carbon quantum dots for achieving rapid assay of tetracyclines in foodstuffs.

The trace-level detection of tetracyclines (TCs) in food products is essential to ensure food safety and public health. Herein, we prepared the methionine-doped carbon quantum dots (Met-CQDs) using citric acid as the precursor. Met-CQDs exhibited a Gaussian unimodal peak centered at 440 nm in the fluorescent excitation spectrum, along with a remarkable greenish-blue emission and a fluorescent quantum yield of 33.

Rapid Detection of Methyl Parathion Based on SiONPs-Eu Dual-Emitting Fluoroprobe and Its On-Site Application.

Herein, we pioneered an innovative methodology for the rapid identification and quantitation of methyl parathion (MP) residues, overcoming the drawbacks of existing methods such as poor selectivity, high costs, and intricate operational procedures. A dual-emitting fluoroprobe SiONPs-Eu was engineered based on silica oxide nanoparticles (SiONPs) conjugated with Eu, and the synthetic conditions were meticulously optimized to ensure exceptional sensitivity and selectivity to 4-nitrophenol (4-NP), one of the MP hydrolytic products. Upon excitation at 317 nm, the blue fluorescence of SiONPs at 400 nm was quenched, while the red fluorescence of Eu at 616 nm remained nearly unchanged, constituting a ratiometric fluorescent change that significantly enhanced the detection stability.

CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1.

C1q/TNF-related protein 13 (CTRP13) is a secreted adipokine that has been shown to play an important role in a variety of cardiovascular diseases. However, the effect of CTRP13 on ferroptosis of endothelial cells and its underlying mechanism remain unclear. In the present study, we analyzed the effects of CTRP13 on endothelial dysfunction in high-lipid-induced ApoE mice and ox-LDL-induced mouse aortic endothelial cells (MAECs).

Effect of legume proteins on the structure and digestibility of wheat starch-lauric acid complexes.

The effect of legume proteins (soy protein (SP), chickpea protein (CP) and peanut protein (PP)) on the properties of wheat starch-lauric acid (WS-LA) system and its intrinsic mechanism were investigated. RVA, digestion experiment and TGA results showed that legume proteins prompted the viscosity peak formation during cooling stage and increased anti-digestion and thermal stability of WS-LA system. FT-IR, Raman, XRD and C NMR results indicated that legume proteins improved the long-range and short-range ordering degree and single-helix structure of WS-LA system.

Indirect photodegradation of pharmaceutical and personal care products in dissolved black carbon solution: The role of microheterogeneous distribution of hydroxyl radical and sorption.

Dissolved black carbon (DBC) with a hyperconjugated structure is ubiquitous in nature, and plays a crucial role in the migration and transformation of environmental contaminants due to its prominent properties of accepting electrons and sorption. However, little is known about the DBC-induced phototransformation of pharmaceutical and personal care products (PPCPs) in natural waters. Herein, the photodegradation kinetics of PPCPs were investigated in DBC solution under simulated solar irradiation and compared with those in Suwannee River natural organic matter (SRNOM) solution.

A critical review of co-pollution of microplastics and heavy metals in agricultural soil environments.

The soil environment is a primary destination for contaminants such as microplastics (MPs) and heavy metals (HMs), which are frequently detected simultaneously. The long-term coexistence of MPs and HMs in the soil necessitates unavoidable interactions, affecting their environmental chemical behavior and bioavailability. These co-contaminants pose potential threats to soil organism growth and reproduction, crop productivity, food security, and may jeopardize human health via the food chain.

Evaluation and driving force analysis of ecological environment in low mountain and hilly regions based on optimized ecological index.

In low mountain and hilly regions, vegetation cover is higher and plant growth has an accumulative effect, sequestering carbon more strongly. The traditional remote sensing based ecological index (RSEI) lacks the consideration of vegetation productivity, and using it to evaluate ecological environment in low mountain and hilly regions will be biased. In this study, the vegetation productivity was introduced to construct a natural remote sensing based ecological index (NRSEI) that responds to the low mountain and hilly regions, as an example of Gaizhou City, China.

Research on adaptive hydraulic drive optimization control of concrete mixing tank truck for open-pit mine.

The non-axisymmetric problem caused by the fluid sloshing in the tank of a mining concrete mixing tank truck during driving is affected by the excitation of complex road surfaces. The fluid sloshing is coupled with the dynamics of the vehicle body due to the excitation of the complex road surface. The traditional hydraulic drive proportional integral differential (PID) control method is not effective in dealing with such problems, which can easily lead to accidents such as overturning.

Single-Step PECVD Synthesis of Graphene@Carbon Nanotubes Electrocatalyst.

Graphene (Gr) and carbon nanotubes (CNTs), the two intriguing carbon nanomaterials, have presented great potential in serving as high-performance electrocatalysts in lithium-sulfur (Li-S) chemistry. The concurrent management of both materials would achieve a promoted synergistic effect. Nevertheless, there still remains a lack of an effective material synthesis route.

Scalable Synthesis of Organic Core/Shell Architectures toward Dual-Wavelength Optical Waveguides.

Organic core/shell heterostructures have undergone rapid progress in materials chemistry owing to the integration of a wide array of unique properties. Nonetheless, the intricate challenge of regulating homogeneous nucleation and phase separation processes in excessively analogous cocrystal structures presents a formidable barrier to expanding the synthesis strategy for organic core/shell heterostructures. Herein, we successfully achieved a phase separation growth process facilitated by the organic alloy interface layer through a dynamic visualization to capture the intricate morphological evolution.

Orbital Adipose Tissue: The Optimal Control for Back-Table Fluorescence Imaging of Orbital Tumors.

Control tissue is essential for ensuring the precision of semiquantitative analysis in back-table fluorescence imaging. However, there remains a lack of agreement on the appropriate selection of control tissues. To evaluate the back-table fluorescence imaging performance of different normal tissues and identify the optimal normal tissue, a cohort of 39 patients with orbital tumors were enrolled in the study.

Lauric acid improved the quality of fresh noodles with/without sodium bicarbonate by altering physical properties and structure of wheat starch.

To know the influence of lauric acid (LA) on wheat flour fresh noodles (WFN) quality and the latent mechanism, the effect of LA on cooking properties, digestibility and structure of WFN with/without sodium bicarbonate (SB) and the properties of wheat flour (WF) with/without SB were studied. The results indicated that LA reduced cooking loss and digestibility of WFN with SB and slightly decreased water adsorption and increased the free water binding ability and hardness of WFN without SB. Furthermore, LA increased the degree of short- and long-range order and molecular weight of starch in cooked WFN with/without SB and it had greater effect on the degree of short- and long-range order and molecular weight of starch in cooked WFN with SB than that without SB.

Epitaxial Growth of Two-Dimensional Organic Crystals with In-Plane Heterostructured Domain Regulation.

Complex organic lateral heterostructures (OLHs) with spatial distribution of two or more chemical components are crucial for designing and realizing unique structure-dependent optoelectronic applications. However, the precise design of well-defined OLHs with flexible domain regulation remains a considerable challenge. Herein, we present a stepwise solution self-assembly method to synthesize two-dimensional (2D) OLHs with a central rhombus domain and a lateral region featuring tunable blue and green emission based on the sequential nucleation and growth of 2D crystals.

N6-methyladenosine modification of linc-OIP5 confers paclitaxel resistance in breast cancer through a DDX5-dependent mechanism.

Chemoresistance is a significant obstacle in the treatment of breast cancer (BC). Due to its diverse composition, the causes of chemoresistance in BC are complex and have not been completely understood. In this article, we explored the mechanism of N6-methyladenosine (m6A)-modified long intervening noncoding RNA (linc)-OIP5 in BC chemoresistance.

Insight into the effect of potassium carbonate on the physicochemical and structural properties of starch isolated from hot-dry noodles.

The objective of this study was to investigate the changes in physicochemical and structural properties of starch isolated from hot-dry noodles (HDNS) treated with different contents of potassium carbonate (KCO). The results demonstrated that the existence of KCO increased the WHC and hardness of HDNS gel with an elevated storage modulus. Meanwhile, KCO promoted the gelatinization of HDNS, which displayed higher viscosity and swelling power.