Publications by authors named "XueDong Shi"
Background: This retrospective cohort study explores a practical approach to acquiring pathogenic microorganisms in patients with bone and joint infections.
Methods: From Aug 2018 to Mar 2022, 68 consecutive patients (87 cultures) with bone and joint infection were recruited in this study. All cultures followed the Peking University First Hospital Procedure of Culturing Pathogenic microorganisms for bone and joint infection.
Targeting TUBB3 Suppresses Anoikis Resistance and Bone Metastasis in Prostate Cancer.
Adv Healthc Mater
November 2024
Article Synopsis
- Bone metastases affect over 70% of advanced prostate cancer patients, contributing to a poor prognosis, and the study highlights the role of anoikis resistance in promoting metastasis.
- The gene TUBB3 is identified as a significant factor in anoikis resistance, showing increased expression in bone metastatic prostate cancer, and its depletion can reverse this resistance and hinder cell invasion and migration.
- The research also introduces bone-targeting lipid nanoparticles (BT-LNP) for effectively delivering siRNA targeting TUBB3, demonstrating potential as a novel therapy to reduce prostate cancer bone metastasis.
Background: Identification of patients with high-risk of experiencing inability to walk after surgery is important for surgeons to make therapeutic strategies for patients with metastatic spinal disease. However, there is a lack of clinical tool to assess postoperative ambulatory status for those patients. The emergence of artificial intelligence (AI) brings a promising opportunity to develop accurate prediction models.
View Article and Find Full Text PDFNon-immune hydrops fetalis (NIHF) is a common and severe manifestation of many genetic disorders. The ultrasound is an ideal method for diagnosing hydrops fetalis during pregnancy. Since most NIHFs do not have an identifiable cause, determining the underlying etiology remains a challenge for prenatal counseling.
View Article and Find Full Text PDFBackground: This study aimed to evaluate the perioperative safety and efficacy of the Mini-open and trans-tubular approach in patients with spinal metastases who underwent decompression surgery.
Methods: 37 consecutive patients with spinal metastases who underwent decompression surgery through a Mini-open or trans-tubular approach were retrospectively reviewed between June 2017 and June 2022. Thirty-four patients were included in this study.
Article Synopsis
- Intraoperative blood loss during surgery for metastatic spinal disease is a major concern, and early identification of high-risk patients is essential for better surgical planning and interventions.
- This study aimed to create and validate a web-based AI model to accurately predict the risk of experiencing massive intraoperative blood loss, defined as blood loss of 2,500 cc or more.
- The research involved 276 patients, using demographic and medical data to develop the AI model, which was tested through internal and external validation processes with different patient cohorts.
Objective: To explore the prognostic value of red blood cell distribution width (RDW) in newly diagnosed aplastic anemia (AA) patients treated with cyclosporine A (CsA) plus androgen or CsA alone.
Methods: We retrospectively analyzed the clinical outcome of 220 patients with AA. According to the baseline level of RDW before treatment, the patients were divided into the high-RDW group (RDW ≥ 15%) and the normal-RDW group (RDW < 15%).
The aim of this study was to investigate the effect of C-reactive protein (CRP) on the prognosis of adult patients with Immune thrombocytopenia purpura (ITP). A retrospective study of 628 adult ITP patients, as well as 100 healthy and 100 infected patients, attending the Affiliated Hospital of Xuzhou Medical University from January 2017 to June 2022 was performed. The ITP patients were grouped according to their CRP levels, and the differences in clinical characteristics of each group and the influencing factors of efficacy in newly diagnosed ITP patients were analyzed.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to create a predictive model and web-based calculator for estimating three-month mortality in patients with bone metastases from cancer of unknown primary (CUP) using machine learning techniques.
- A total of 1,010 patients were analyzed using data from the SEER database and split into two groups for training and validation of the models, evaluating their prediction accuracy through various metrics.
- Results indicated a high mortality rate of 72.38%, with factors like older age and organ-specific metastases increasing risk, while treatment methods such as radiation and chemotherapy provided protective benefits, with the random forest model proving most effective in predictions.
Article Synopsis
- The study aimed to determine how manual homogenization (MH) affects microbiological culture sensitivity in patients with pyogenic spondylitis, using samples obtained from biopsies or surgeries.
- A total of 24 patients (33 tissue cultures) were analyzed, with results showing that the MH method had significantly higher positive culture rates compared to manual mixing (MM) for both aerobic and anaerobic conditions.
- The findings suggest that manual homogenization can enhance culture sensitivity, particularly in patients who have previously used antibiotics or who do not have paravertebral abscesses.
Purpose: Bone is one of the most common sites for the spread of malignant tumors. Patients with bone metastases whose prognosis was shorter than 3 months (early death) were considered as surgical contraindications. However, the information currently available in the literature limits our capacity to assess the risk likelihood of 3 month mortality.
View Article and Find Full Text PDFMachine learning in predicting cardiac surgery-associated acute kidney injury: A systemic review and meta-analysis.
Front Cardiovasc Med
September 2022
Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication following cardiac surgery. Early prediction of CSA-AKI is of great significance for improving patients' prognoses. The aim of this study is to systematically evaluate the predictive performance of machine learning models for CSA-AKI.
View Article and Find Full Text PDFObjective: To investigate the significance of lysosomal protein transmembrane 5 (LAPTM5) in kidney renal clear cell carcinoma (KIRC).
Methods: Bioinformatics analysis as an efficient and accurate method was employed to explore the expression levels, prognostic significance, and regulatory pathways of LAPTM5 in KIRC. Finally, the association of LAPTM5 with tumor immune infiltrates was initially investigated.
Article Synopsis
- This study evaluated the safety and effectiveness of minimally invasive tubular surgery for patients with spinal metastasis, comparing it to conventional surgery.
- The results indicated that minimally invasive surgery resulted in less blood loss, shorter drainage times, and reduced hospital stays compared to conventional methods, although overall complication rates were similar.
- Patients with hypo-vascular tumors benefited more from this technique, showing significant improvements in blood loss and recovery times.
The bottleneck arising from castration-resistant prostate cancer (CRPC) treatment is its high metastasis potential and antiandrogen drug resistance, which severely affects survival time of prostate cancer (PCa) patients. Secreted phosphoprotein 1 (SPP1) is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. In our previous study, we firstly revealed SPP1 was a potential hub signature for predicting metastatic CRPC (mCRPC) development.
View Article and Find Full Text PDFRisk factors of total blood loss in the posterior surgery for patients with thoracolumbar metastasis.
BMC Musculoskelet Disord
October 2021
Background: Blood loss in posterior surgery patients with thoracolumbar metastasis posed a significant challenge to surgeons. This study aimed to explore the risk factors of blood loss in posterior surgery for patients with thoracolumbar metastasis.
Methods: One hundred forty-two patients were retrospectively reviewed.
Purpose: This study aimed to assess the risk variables for predicting intra-spinal canal cement leakage, especially among elderly patients with spine metastases after being treated with percutaneous vertebroplasty (PVP). Furthermore, we proposed and validated a nomogram to stratify risks of intra-spinal canal cement leakage.
Methods: We retrospectively analyzed 163 elderly patients (age ≧65 years) with spine metastases who underwent PVP.
Objective: This study aimed to investigate the effect of timing of surgery on neurological recovery for patients with metastatic spinal cord compression (MSCC).
Methods: According to the timing of surgery, 75 patients with incomplete paraplegia caused by MSCC were assigned to 3 groups: within 3 days (group A), between 4 days and 7 days (group B), and after 7 days (group C). -test, one-way ANOVA, Mann-Whitney -test, and Chi-square test were used to evaluate the difference in the improvement of American Spinal Injury Association Impairment Scale (AIS) and ambulatory status, the incidence of perioperative complications, surgical site infection, and the length of hospital stay between 3 groups.
Background: Cement leakage into venous blood posed significant challenge to surgeons. The aim of the study was to create a Peking University First Hospital Score (PUFHS) which could evaluate the probability of vascular cement leakage among spine metastases patients following percutaneous vertebroplasty.
Methods: The study retrospectively enrolled 272 spine metastases patients treated with percutaneous vertebroplasty.
Article Synopsis
- - The study aimed to explore the prevalence of cement leaks in advanced cancer patients undergoing a procedure called percutaneous vertebroplasty and to create an algorithm for predicting which patients are at higher risk of experiencing these leaks.
- - Researchers analyzed data from 309 patients, identifying 13 characteristics associated with a higher likelihood of cement leaks, such as younger age and the presence of other bone metastases, resulting in a scoring system to indicate risk levels.
- - The developed algorithm showed good predictive ability, with accuracy rates of about 73.5% for the training group and 64.9% for the validation group, confirming that cement leaks are common and providing a tool for identifying at-risk patients.
Background: The study aimed to identify the risk factors of cement leakage following percutaneous vertebroplasty for spinal metastases.
Methods: 230 consecutive patients with 530 vertebrae were retrospectively reviewed. Characteristics including age, primary cancer, location, pathological fracture, the integrity of the posterior wall, and the volume of bone cement were considered as potential risk factors.
Purpose: The study aims to investigate and compare the efficacy and safety of intraoperative I implantation and postoperative irradiation after surgical decompression and stabilization in the treatment of patients with metastatic epidural spinal cord compression (MESCC).
Methods: The study retrospectively enrolled 122 MESCC patients treated with surgical decompression and pedicle stabilization combined with I brachytherapy (the brachytherapy group) or postoperative radiotherapy (the irradiation group). Operation time, intraoperative blood loss, pain relief, postoperative ambulatory status, postoperative survival outcome, complications, and length of hospitalization were collected and compared between the two groups.
Various survival scoring systems have been developed to help surgeons select the best candidates for appropriate therapies in patients with metastatic spinal disease. This study aims to discuss the current status and future directions of scoring systems for the prediction of survival prognosis in these patients. The search terms "spine metastases," "metastatic spinal disease," and "metastatic spinal cord compression" were combined with "survival prognosis," "scoring system," and "score" to elicit relevant literatures in PubMed and Embase databases.
View Article and Find Full Text PDFPurpose: This study aims to develop an algorithm to predict cement injection volumes in patients with spine metastases treated with percutaneous vertebroplasty (PVP). Risk factors were also analyzed for intra-spinal canal cement leakages.
Patients And Methods: A retrospective analysis of 584 vertebrae in 251 patients.