Publications by authors named "Xue-zhen Yu"
Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of autism spectrum disorder (ASD) has not yet been achieved. We developed an apolipoprotein B messenger RNA-editing enzyme, catalytic polypeptide-embedded cytosine base editor (AeCBE) system for converting C·G to T·A base pairs. We demonstrate its effectiveness by targeting AeCBE to an ASD-associated mutation of the MEF2C gene (c.
View Article and Find Full Text PDFlncRNA-XIST protects the hypoxia-induced cardiomyocyte injury through regulating the miR-125b-hexokianse 2 axis.
In Vitro Cell Dev Biol Anim
April 2020
Ischemic injury in the heart is associated with low oxygen, leading to the damage of cardiomyocytes. The lncRNA-XIST is known to involve in post-ischemia myocardial remodeling. However, the roles and mechanism of XIST in the hypoxia-induced cardiomyocyte are still under investigation.
View Article and Find Full Text PDF[Investigation on clozapine poisoning in one enterprise].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
September 2010
Article Synopsis
- A new technique using medium biofilms and aquatic plants was tested in Shanghai to address water eutrophication, with promising results in removing pollutants.
- The pilot study involved analyzing water quality from connected ponds and highlighted that ponds with hydrophytes showed significantly better removal rates for nitrogen and phosphorus compared to those without.
- ERIC-PCR fingerprinting revealed that ponds with plants had more similar and diverse microbial communities, correlating with improved pollution removal efficiencies over time.
[Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].
Zhonghua Yu Fang Yi Xue Za Zhi
July 2004
Objective: To study the mechanism of male reproductive toxicity of metadoxine (MTDX) on mice and rats.
Methods: Mouse multiple endpoints assay and Hershberger assay were employed to evaluate the potential estrogenic and/or antiandrogenic effects of MTDX. In mouse multiple endpoints assay, MTDX (0, 640, 1500 and 4000 mg/kg, respectively) were administered once daily p.