Mechanisms underlying the effects of the conditional knockdown of hepatic PCSK9 in attenuating lipopolysaccharide-induced acute liver inflammation.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is known to promote hyperlipidemia primarily by inducing the degradation of the low-density lipoprotein receptor. Notably, recent studies have demonstrated that PCSK9 promotes inflammation in the vascular system, however, the roles of PCSK9 in hepatic inflammation remain unclear. As PCSK9 is primarily expressed in the liver, this study aimed to elucidate the roles of PCSK9 and the underlying mechanisms in lipopolysaccharide (LPS)-challenged hepatocytes.

Magnetic resonance imaging (MRI) and clinical features of different parts of the pancreas involved in acute pancreatitis: a cross-sectional study.

Background: Patients with acute pancreatitis (AP) have different sites of pancreatic involvement. The aim of this study was to investigate the differences in magnetic resonance imaging (MRI) findings and clinical features of different sites of involvement (subtypes) in AP, with a view to complement and complete the classification of AP based on anatomical imaging features.

Methods: We consecutively collected data from inpatients with AP from January 2018 to October 2022 at a tertiary care hospital.

[Mechanism of Transportation Capacity Influence on Carbon Emission of Transportation Sector at China Provincial Scale from a Spatial Perspectiv].

Transportation carbon emissions （TCE） are a major contributor to emissions, and their emission reduction pathway can provide recommendations for the overall carbon emission reduction decision-making. Therefore, identifying the impact mechanism of transportation capacity on TCE through scientific methods has become an important foundation to respond to the national "dual-carbon" strategy. Based on the panel data of 30 provinces in China from 2012 to 2021, a dynamic spatial dubin model （SDM） was included to empirically analyze the dynamic spatial spillover effects of transportation capacity on carbon emissions from China's transportation sector, taking correlation and heterogeneity into account.

Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review.

Despite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vascular homeostasis. Notably, a variety of cells produce and secrete platelet-derived growth factors (PDGFs), which promote mitosis and induce the division, proliferation, and migration of vascular cells including vascular smooth muscle cells (SMCs), aortic SMCs, endothelial cells, and airway SMCs.

Anti-inflammatory Fatty Acid Derivatives From Mangrove-derived Actinomycetes Streptomyces sp.

Mangrove-derived actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the mangrove-derived Streptomyces sundarbansensis 06037, led to the discovery of two previously undescribed enone fatty acids (1-2), one new phenylpropionate derivate (3), along with the isolation of the ten known components (4-13). Those chemical structures of isolates were elucidated on the basis of the analysis of diverse spectroscopic data.

Correction: A comparative study of the hypolipidemic effects and mechanisms of action of - and -derived fucoidans in apolipoprotein E-deficient mice.

Correction for 'A comparative study of the hypolipidemic effects and mechanisms of action of - and -derived fucoidans in apolipoprotein E-deficient mice' by Tian Liu , , 2024, , 5955-5971, https://doi.org/10.1039/D3FO05521C.

Specialized Metabolites from the Husks of Rice Oryza Sativa L. and their Biological Activities.

Rice (Oryza sativa L.) husk harbors a substantial proportion of biological metabolites, as one of the most plentiful agriculture by-products in rice milling process, rice husk remains poorly utilized. As a continuing search for potential bioactive molecules from the husk of rice, a totally of twelve components (1-12), including six sterol ferulates (1-6), one flavonoid (7), one dipeptide (8), and four phenylpropanoid derivatives (9-12) were obtained.

Heterologous Expression and Characterization of a pH-Stable Chitinase from with a Potential Application in Chitin Degradation.

To promote the bioconversion of marine chitin waste into value-added products, we expressed a novel pH-stable -derived chitinase, Chi1, in and subsequently purified, characterized, and evaluated it for its chitin-converting capacity. Our results indicated that Chi1 is of the glycoside hydrolase (GH) family 18 with a molecular weight of approximately 57 kDa, consisting of a GH18 catalytic domain and a cellulose-binding domain. We recorded its optimal activity at pH 5.

Ultrathin zigzag-surface copper nanowire assembled hierarchical microspheres to enhance oxygen reduction catalysis.

Ultrathin catalysts predominantly expose surface active atoms to deliver promising applications in oxygen reduction reactions (ORRs). However, they are commonly synthesized at high reaction temperatures, with tedious chemical routes involved. Herein, we report a low temperature (273 K) electric field driven route to synthesize zigzag-surface ultrathin copper nanowires.

A comparative study of the hypolipidemic effects and mechanisms of action of - and -derived fucoidans in apolipoprotein E-deficient mice.

The structural characteristics of fucoidans exhibit species and regional diversity. Previous studies have demonstrated that - and -derived fucoidans have type I and type II fucosyl chains, respectively. These chemical differences may contribute to distinct hypolipidemic effects and mechanisms of action.

The function of brown adipose tissue at different sites of the body in Brandt's voles during cold acclimation.

Ambient temperatures have great impacts on thermoregulation of small mammals. Brown adipose tissue (BAT), an obligative thermogenic tissue for small mammals, is localized not only in the interscapular depot (iBAT), but also in supraclavicular, infra/subscapular, cervical, paravertebral, and periaortic depots. The iBAT is known for its cold-induced thermogenesis, however, less has been paid attention to the function of BAT at other sites.

Fe-doped g-CN with duel active sites for ultrafast degradation of organic pollutants via visible-light-driven photo-Fenton reaction: Insight into the performance, kinetics, and mechanism.

The photo-Fenton process provides a sustainable and cost-effective strategy for removing refractory organic contaminants in wastewater. Herein, a high-efficient Fe-doped g-CN photocatalyst (Fe@CN) with a unique 3D porous mesh structure was prepared by one-pot thermal polymerization for ultrafast degradation of azo dyes, antibiotics, and phenolic acids in heterogeneous photo-Fenton systems under visible light irradiation. Fe@CN exhibited a synergy between adsorption-degradation processes due to the co-existence of FeC and FeN active sites.

Modified Sijunzi Granules Exhibit Hemostatic Effect by Activating Akt and Erk Signal Pathways via Regulating 5-HT and Its Receptors Levels.

Objective: To investigate the hemostatic effect of modified Sijunzi Granules (MSG) in primary immune thrombocytopenia (ITP) zebrafish model and explore the potential mechanism.

Methods: AB strain wild type zebrafish were treated with simvastatin (6 µmol/L) for 24 h to establish the hemorrhage model (model control group). The zebrafish were treated with MSG at different doses (55.

Room temperature solid-state deformation induced high-density lithium grain boundaries to enhance the cycling stability of lithium metal batteries.

Due to its high theoretical capacity and low anode potential advantages, lithium is becoming the ideal high-capacity anode of next generation batteries. Nevertheless, the satisfactory long-term cyclability of lithium metal batteries is still not achieved. Inspired by the intrinsic soft nature of the lithium metal, we have developed a simple room temperature solid-state deformation route to overcome the lithium dendrite issue, and the cycle life of the deformation treated lithium anode is 5 times that of the untreated lithium anode.

Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus).

In photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process. The beneficial effects of MT in delaying the progress of ageing have been reported in laboratory mice and rats. However, little is known about MT in wild mammals.

Reductive Catalytic Difluorocarbene Transfer via Palladium Catalysis.

A palladium-catalyzed reductive difluorocarbene transfer reaction that tames difluorocarbene to couple with two electrophiles has been developed, representing a new mode of difluorocarbene transfer reaction. The approach uses low-cost and bulk industrial chemical chlorodifluoromethane (ClCF H) as the difluorocarbene precursor. It produces a variety of difluoromethylated (hetero)arenes from widely available aryl halides/triflates and proton sources, featuring high functional group tolerance and synthetic convenience without preparing organometallic reagents.

AKTeO(CO) (A = Li, Na): The First Carbonatotellurites Featuring a Zero-Dimensional [TeCO] Cluster and a Wide Band Gap.

The first carbonatotellurites, AKTeO(CO) (A = Li, Na), have been successfully synthesized by using boric acid as the mineralizer. AKTeO(CO) (A = Li, Na) crystallize in the monoclinic space group 2/ (no. 14), and their structures exhibit the novel zero-dimensional (0D) [TeCO] clusters, in which two [TeO] groups form a [TeO] dimer via edge-sharing, with each side of the dimer attached by a [CO] group via a Te-O-C bridge.