Publications by authors named "Xue-yan Chen"

Article Synopsis
  • This study assembled a detailed genome for Castanopsis eyrei and sequenced genomes from 276 individuals across 12 Castanopsis species to explore genomic variation.
  • The researchers found correlated genomic landscapes among species, with genetic diversity and differentiation linked to recombination rates and gene density, suggesting long-term evolutionary processes have influenced these patterns.
  • The results indicated that both background selection and recurrent selective sweeps are important in explaining genomic variation, alongside extensive gene flow and adaptive introgression, which have shaped the genomes of hybrid species.
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The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes (KCs). KCs and melanocytes respond to UV exposure by eliciting a tanning response. However, how KCs and melanocytes interact in the absence of UV exposure is unknown.

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Lithocarpus, with >320 species, is the second largest genus of Fagaceae. However, the lack of a reference genome limits the molecular biology and functional study of Lithocarpus species. Here, we report the chromosome-scale genome assembly of sweet tea (Lithocarpus polystachyus Rehder), the first Lithocarpus species to be sequenced to date.

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Article Synopsis
  • - Atopic dermatitis (AD) is a common inflammatory skin disease linked to issues like skin barrier dysfunction and immune system dysregulation, with STAT3 playing a key role in skin cell function.
  • - Researchers created a mouse model with specific loss of STAT3 in skin cells, which showed worsened AD-like symptoms after exposure to a skin irritant, indicating a negative impact on skin health and microbiome composition.
  • - The study found that mice with STAT3 deficiency exhibited more type-2 inflammatory cells and increased levels of TSLP, a protein that attracts immune cells, suggesting that targeting TSLP could help reduce skin inflammation in AD.
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Article Synopsis
  • Psoriasis involves excessive skin cell growth and immune cell infiltration, with the exact causes remaining uncertain.
  • Researchers found that glycyl-tRNA synthetase (GARS), typically involved in protein synthesis, is overexpressed in the skin and blood of psoriasis patients, promoting skin inflammation and abnormal growth when present in high levels.
  • The study suggests that targeting GARS could be a potential new treatment strategy for psoriasis, as reducing its expression showed improvements in inflammation and skin condition in laboratory models.
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Breast cancer is the most prevalent malignancy among women. Doxorubicin (Dox) resistance was one of the major obstacles to improving the clinical outcome of breast cancer patients. The purpose of this study was to investigate the relationship between the FABP signaling pathway and Dox resistance in breast cancer.

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The skin is the outermost barrier that separates the human body from the external environment. In psoriasis, immune cells reside within or infiltrate the epidermis to form the epidermal (epithelial) immunological microenvironment (EIME) and engage in complex interactions with keratinocytes, nerves, and microbiota. The proposed hypothesis is that psoriasis is a chronic inflammatory disease mainly mediated by a specific inflammatory environment composed of keratinocyte-neuro-immune cell units (KNICUs).

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Fagaceae species dominate forests and shrublands throughout the Northern Hemisphere, and have been used as models to investigate the processes and mechanisms of adaptation and speciation. Compared with the well-studied genus , genomic data is limited for the tropical-subtropical genus . is an ecologically and economically valuable species with a wide distribution in the evergreen broad-leaved forests of tropical-subtropical Asia.

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Understanding the evolutionary processes that shape the landscape of genetic variation and influence the response of species to future climate change is critical for biodiversity conservation. Here, we sampled 27 populations across the distribution range of a dominant forest tree, Quercus acutissima, in East Asia, and applied genome-wide analyses to track the evolutionary history and predict the fate of populations under future climate. We found two genetic groups (East and West) in Q.

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Proinflammatory cytokines, such as IL-1β, are important mediators of psoriasis. UBE2L3, an E2 enzyme, is thought to be an indirect target of IL-1β secretion by binding to ubiquitin ligases such as TRIM21. However, its role in psoriasis remains unknown.

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Background: The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed to investigate the mechanisms underlying the efficacy of IARS inhibitor, mupirocin, treatment for psoriasis.

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Article Synopsis
  • Psoriasis is a chronic inflammatory skin condition, and recent research aims to clarify the distribution of immune cells in psoriatic skin at a single-cell level.
  • Using mass cytometry, researchers identified specific dendritic cells (DCs) in psoriatic skin samples that migrate and replace other immune cells, contributing to skin inflammation.
  • The study highlights that the immune environment in the epidermis (the outer layer of skin) plays a crucial role in psoriasis, with various immune cells working together to regulate inflammation and maintain skin health.
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Secukinumab is a recombinant, fully human monoclonal anti-IL-17A antibody approved to treat moderate-to-severe psoriasis and psoriatic arthritis. Its effectiveness and safety have been confirmed, but a gradual increase in the secukinumab dosing interval has not been investigated. To assess the feasibility, efficacy, and safety of gradually increasing the secukinumab dosing interval; the interval duration was determined by changes in the Psoriasis Area and Severity Index scores.

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Objectives: Psoriasis is an immune-mediated skin disease dominated by the cutaneous immune system. Keratinocytes have been considered important triggers that initiate psoriasis. The key molecules and events of keratinocytes that link the innate immune system in psoriasis must be investigated in more detail.

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Article Synopsis
  • * Nerve fibers in affected skin are closely associated with immune cells and keratinocytes, and disruptions in sensory nerve-related genes were found in psoriasis.
  • * Treatments that impair skin nerves, like botulinum toxin A, have been found to reduce psoriasiform dermatitis, indicating that targeting the nervous system could offer new therapeutic options for psoriasis.
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The strength of selection varies among populations and across the genome, but the determinants of efficacy of selection remain unclear. In this study, we used whole-genome sequencing data from 467 Boechera stricta accessions to quantify the strength of selection and characterize the pattern of local adaptation. We found low genetic diversity on 0-fold degenerate sites and conserved non-coding sites, indicating functional constraints on these regions.

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Psoriasis is a systemic immune‒mediated inflammatory disease characterized by hyperproliferation and abnormal differentiation of epidermal keratinocytes. Recent studies have identified IL-17 and IL-23 as key drivers of psoriasis pathogenesis, but the underlying molecular mechanisms remain unclear. The 2'-5'-oligoadenylate synthetases (OASs), namely, OAS1, OAS2, OAS3, and OASL, are a family of IFN-induced enzymes with multiple antiviral activities, but their role in psoriasis is unknown.

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Northern Hemisphere forests changed drastically in the early Eocene with the diversification of the oak family (Fagaceae). Cooling climates over the next 20 million years fostered the spread of temperate biomes that became increasingly dominated by oaks and their chestnut relatives. Here we use phylogenomic analyses of nuclear and plastid genomes to investigate the timing and pattern of major macroevolutionary events and ancient genome-wide signatures of hybridization across Fagaceae.

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Psoriasis is a chronic multisystem inflammatory disease that affects ~0.1-1.5% of the world population.

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Natural selection shapes genome-wide patterns of diversity within species and divergence between species. However, quantifying the efficacy of selection and elucidating the relative importance of different types of selection in shaping genomic variation remain challenging. We sequenced whole genomes of 101 individuals of three closely related oak species to track the divergence history, and to dissect the impacts of selective sweeps and background selection on patterns of genomic variation.

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Article Synopsis
  • Psoriasis is a chronic inflammatory disease that impacts skin health, highlighting the role of epidermal proteins in skin barrier function and immunity.
  • A study compared epidermal proteins between psoriasis patients and healthy individuals, finding key proteins that were elevated, particularly antimicrobial peptides (AMPs) and antiviral proteins (AVPs), with OAS2 levels correlating to disease severity.
  • OAS2 arises mainly from inflamed skin cells and can potentially serve as a biomarker for psoriasis severity and treatment effectiveness, showing promise for future clinical applications.*
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Aconitine (ACO), a main active ingredient of Aconitum, is well-known for its cardiotoxicity. However, the mechanisms of toxic action of ACO remain unclear. In the current study, we investigated the cardiac effects of ACO and mesaconitine (MACO), a structurally related analog of ACO identified in Aconitum with undocumented cardiotoxicity in guinea pigs.

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