[Different patterns of abnormalities in exercise 201TI myocardial scintigraphy and their mechanisms].

Objective: To categorize the patterns of abnormalities in exercise (201)TI myocardial scintigraphy and explore the mechanisms.

Methods: Exercise (201)TI myocardial scintigraphy was performed in 203 patients with clinically suspected coronary artery disease, including 74 normotensive patients, 78 hypertensive patients without left ventricle hypertrophy (LVH) and 51 hypertensive patients with LVH. All the patients underwent coronary angiography one month before or after (201)TI myocardial scintigraphy, and the patterns of abnormal findings were categorized as segmental, non-segmental and mixed patterns.

[Association of platelet endothelial cell adhesion molecule-1 gene polymorphism with coronary heart disease].

Objective: To investigate the association of Leu125Val and Ser563Asn polymorphism of the gene encoding platelet endothelial cell adhesion molecule-1(PECAM-1) with coronary heart disease.

Methods: This study included 156 patients with the diagnoses of coronary heart disease (CHD) and coronary lesions derived from electrocardiography, myocardial enzyme analysis and coronary angiography as the CHD group, and another 75 in-patients admitted within the same period who showed no signs of CHD in the above examinations constituted the control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to examine the missense polymorphism of PECAM-1gene in the position of Leu125Val and Ser563Asn.

[Protective effects of preconditioning phlebotomy against myocardial ischemia-reperfusion injury in rat].

Objective: To investigate the protective effect of preconditioning phlebotomy against ischemia-reperfusion injury and the role of calcitonin gene-related peptide (CGRP) in this protection mechanism.

Methods: Sixty SD rats were randomly assigned in equal number into control, phlebotomy, and CGRP polyclonal antibody (PcAb) groups, all of which were subjected to 30 min regional ischemic followed by two-hour reperfusion, initiated 15 min after phlebotomy in the latter 2 groups. The rats in CGRP PcAb group were given the antibody (2.

Thallium-201 myocardial scintigraphy in hypertensive patients with and without left ventricular hypertrophy: a clinical study.

OBJECTIVE: To evaluate the myocardial perfusion in hypertensive patients with and without left ventricular hypertrophy using thallium-201 (201TI) myocardial scintigraphy and explore the mechanism that causes the perfusion abnormalities. METHODS: Thallium-201 myocardial scintigraphy was performed in 85 patients with clinically suspected coronary artery disease to assess the myocardial perfusion status. For patients with myocardial perfusion abnormalities as indicated by the scintigraphy, coronary angiography was ordered within 1 month.

[Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy].

Objective: To investigate the relationship between aldosterone synthase (CYP11B2) gene polymorphism and hypertrophic cardiomyopathy (HCM).

Methods: Fifteen HCM patients and 18 healthy subjects were enrolled in this study. Peripheral blood samples were collected from these subjects to exact genome DNA.

A Method of the Simultaneous Purification of Cardiac Troponin T and I.

A method of the simultaneous purification of cardiac troponin T (cTnT) and troponin I (cTnI) from human cardiac left ventricular muscle have been developed. Five mg cTnT and 10.2 mg of cTnI were obtained from 100 mg of cardiac muscle.