Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer's disease diagnosis and differential diagnosis.

Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer's disease (AD). The study began with searching for novel blood-based neuronal extracellular vesicles (EVs) that are more enriched in the brain regions vulnerable to AD development and progression. With extensive proteomic profiling, GABRD and GPR162 were identified as novel brain regionally enriched plasma EVs markers.

[Application of oxytocin antagonists in thaw embryo transfer].

Objective: To study the effects of oxytocin antagonists-atosiban on pregnancy outcome after thaw embryo transfer (TET).

Methods: Between Jul. and Dec.

Modified super-long down-regulation protocol improves fertilization and pregnancy in patients with poor ovarian responses.

Background: The successful end-point of in vitro fertilization (IVF) treatment is for a woman to give live birth. This outcome is based on various factors including adequate number of retrieved eggs. Failure to recruit adequate follicles, from which the eggs are retrieved, is called a "poor response".

[Influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization-embryo transfer].

Objective: To study the influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization (IVF)-embryo transfer (ET).

Methods: From August 2010 to January 2011, 243 infertile patients in Reproductive Medical Center of Tianjin Medical University General Hospital who underwent IVF or intracytoplasmic sperm injection (ICSI) were divided into two groups, including 129 cases used EmbryoGlue as the embryo transfer medium in experimental group and 114 cases used G-2 as embryo transfer medium in control group. Pregnancy outcome were compared between two groups.

[Extracellular signal-regulated protein kinase activation in endometrium with polycystic ovary syndrome and its significance].

Objective: to investigate the activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling pathway in the endometrium of women with polycystic ovary syndrome (PCOS) and its effect and significance in the cause of hyperplasia and carcinoma; and investigate the factors which affect the activation of the MAPK/ERK signaling pathway.

Methods: collected 52 patients diagnosed as PCOS who were taken dilation and curettage of uterus as study, while 32 non-PCOS patients matched as control group. Serum hormonal parameters, fasting blood glucose and insulin were measured in all patients.

[Influence of embryo transfer depth on in vitro fertilization and embryo transfer outcomes].

Objective: To investigate the influence of transfer distance from the fundus on clinical pregnancy rate and implantation rate in in vitro fertilization and embryo transfer.

Methods: A total of 98 patients (108 cycles) undergoing ultrasound-guided embryo transfer were divided into two groups according to the distance between the tip of catheter and the uterine fundus: group A: > or = 5 - < 10 mm, group B: > or = 10 - < or = 15 mm.

Results: Clinical pregnancy rate and implantation rate were significantly higher in group B compared with group A [44 % (23/52) vs 25% (14/56), 24% (28/115) vs 14% (17/121), P < 0.