Publications by authors named "Xue-ru Feng"
BACKGROUND Aspirin hyporesponsiveness increases the risk of ischemic events. Therefore, it is important to investigate the factors influencing aspirin hyporesponsiveness. MATERIAL AND METHODS Patients aged 60 years or older who did not take aspirin before enrollment were included, with aspirin 100 mg/day administered after enrollment.
View Article and Find Full Text PDFTriptolide (TP) is the main active ingredient of Tripterygium wilfordii Hook.f, which has attracted great interest due to its promising efficacy for autoimmune diseases and tumors. However, severe adverse reactions, especially hepatotoxicity, have restricted its approval in the market.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate the relationship between urinary 11-dehydro-thromboxane B2 (11dhTxB2) levels and how well aspirin works in patients with type 2 diabetes and coronary artery disease (CAD).
- Involving 169 elderly patients, the study measured urinary 11dhTxB2 levels to classify them into high aspirin platelet reactivity (HAPR) and No-HAPR groups, with high levels indicating low response to aspirin.
- Results showed that patients had significantly lower urinary 11dhTxB2 levels after aspirin treatment, and those in the HAPR group experienced worse outcomes, suggesting urinary 11dhTxB2 levels could be a useful tool for assessing aspirin effectiveness in this
[Association between CMTM5 gene rs723840 single nucleotide polymorphism and high on asprin platelet reactivity].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2015
Article Synopsis
- The study investigates the link between the CMTM5 gene rs723840 polymorphism and high on aspirin platelet reactivity (HAPR) in coronary artery disease patients.
- A total of 210 hospitalized patients were divided into HAPR and No-HAPR groups based on their aspirin response, assessed through platelet aggregation tests.
- The findings revealed a significant difference in genotype and allele frequencies between the two groups, indicating that the rs723840 polymorphism is associated with HAPR.
[The clinical features of gastrointestinal bleeding complicating aortic stenosis].
Zhonghua Nei Ke Za Zhi
September 2013
Objective: To deepen the understanding about Heyde's syndrome by investigating the clinical characteristics and prognosis of the patients with aortic valve stenosis complicating with gastrointestinal bleeding.
Methods: Patients with aortic valve stenosis and gastrointestinal bleeding coincidently admitted to our hospital from 2001 to 2011 were retrieved and analyzed.
Results: In all the 443 157 in-patients, 474 patients were diagnosed with aortic valve stenosis (0.
Article Synopsis
- American Ginseng and Corydalis Tuber have been traditionally used to treat cardiovascular diseases due to their beneficial effects, and this study aims to evaluate the anti-apoptotic properties of Shenyuan, which is derived from these plants.
- In a porcine model of acute myocardial infarction, various doses of Shenyuan and Metoprolol were tested, and both treatments significantly reduced the apoptotic index and cardiac enzyme release, indicating less heart damage.
- Shenyuan treatment effectively decreased oxidative stress markers, balanced anti-apoptotic and pro-apoptotic factors, and inhibited caspase-3 activation, showcasing its potential as a protective agent in heart-related issues.
[New selection of antiplatelet agents among patients with coronary heart disease].
Zhonghua Yi Xue Za Zhi
October 2012
[Aspirin response and related factors in aged patients].
Zhonghua Xin Xue Guan Bing Za Zhi
October 2011
Objective: To explore clinical and laboratory factors associated aspirin response, and the association between gastrointestinal bleeding and aspirin response in aged patients.
Methods: A total of 136 patients aged 60 and over [mean age (74.9 ± 7.
[The predictive value of Holter recordings to detect moderate-severe obstructive sleep apnea syndrome].
Zhonghua Xin Xue Guan Bing Za Zhi
December 2009
Objective: To evaluate the predictive value of Holter ECG recordings for patients with moderate-severe obstructive sleep apnea and hypopnea syndrome (OSAHS).
Methods: Holter recordings was performed in 76 patients who were diagnosed OSAHS by polysomnography (PSG) within one month from Jan. 2008 to July 2009 in our hospital.
[Relationship between plasma cortistatin and coronary heart disease].
Beijing Da Xue Xue Bao Yi Xue Ban
October 2009
Objective: To analyze the relationship between plasma level of cortistatin(CST) and coronary heart disease(CHD) and the factors that influence the level of CST.
Methods: Plasma levels of CST were measured using ELISA method. The clinical data and the levels of CST of 40 healthy subjects and 39 CHD patients before and 1 d after percutaneous coronary intervention (PCI) were compared.
[Effects of in vivo transfer of human chemokine-like factor 1 gene on cardiac function after acute myocardial infarction in rats].
Beijing Da Xue Xue Bao Yi Xue Ban
April 2009
Objective: To study the effects of chemokine-like factor 1(CKLF1)-plasmid transfer on cardiac function in a rat acute myocardial infarction (AMI) model.
Methods: Thirty male SD rats were randomly devided into 3 groups. One hundred micrograms of CKLF1-plasmid, empty plasmid or saline were injected intramuscularly with in vivo electroporation, respectively.
[In vivo transfer of human chemokine-like factor 1 gene increases peripheral blood CD34+ stem cells after myocardial infarction in rats].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2006
Objective: To assess the influence of different doses of CKLF1 plasmid on the dynamics and magnitude of the mobilization of the mobilization bone of marrow stem cells in a rat AMI model.
Methods: Different doses of plasmid DNA encoding CKLF1 gene, empty plasmid or saline were injected into male SD rats intramuscularly with in vivo electroporation. Rats were subjected to left coronary artery ligation 6 days after gene transfer.