Publications by authors named "Xue-rong Zhao"
Background: Pepsinogen C (PGC) is expressed in chief cells, fundic mucous neck cells, and pyloric gland cells of gastric epithelium and also in breast, prostate, lung, and seminal vesicles.
Methods: We explored the clinicopathological and prognostic significances of PGC mRNA using pathological and bioinformatics analyses. We generated PGC knockout and PGC-cre transgenic mice to observe the effects of PGC deletion and PTEN abrogation in PGC-positive cells on gastric carcinogenesis.
Three new diterpenoids, named nematocynine A-C (1-3), together with twelve known compounds (4-15) were isolated from the aerial part of Hand.-Mazz (Hereinafter referred to ). Their structures were elucidated by detailed spectroscopic analysis and comparison with literature data.
View Article and Find Full Text PDFFourteen undescribed seco-type diterpenoids, named nudifloids A-N, together with ten known analogs, were isolated from the leaves of Callicarpa nudiflora. Nudifloids A-N had a characteristic 3,4-seco-labdane-type diterpenoid skeleton, whereas nudifloids A-C and K-N were 3,4-seco-norditerpenoids. Nudifloid A was the first example of a 3,4-seco-12,13,14,15,16-quartnor-labdane diterpenoid, with a seven-membered lactone ring formed through esterification between C-3 and C-11.
View Article and Find Full Text PDFArticle Synopsis
- Five new labdane diterpenoids (Stevelins A-E) and three known labdane diterpenoids were identified from the plant Stevia rebaudiana.
- The structures of these compounds were determined using NMR spectroscopy, high-resolution mass spectrometry, and X-ray crystallography, with additional insights from electronic circular dichroism calculations.
- Most of the isolated compounds showed significant effects in inhibiting foam cell formation induced by oxidized low-density lipoprotein, indicating their potential as treatments for atherosclerosis.
Article Synopsis
- - Ten new flavonoids, called denticulains A-J, were discovered in the plant Macaranga denticulata, along with seven previously known flavonoids.
- - The structures of these compounds were determined using advanced techniques and by comparing them with existing data.
- - Two specific compounds (denticulain A and another known flavonoid) showed the ability to inhibit cancer cell growth in lab tests, with respective IC values of 46.08 μM and 56.83 μM.
Article Synopsis
- Three new compounds called Callicarpnoids A-C were discovered from the stems of Callicarpa arborea, and their structures were determined using advanced techniques like spectroscopic analysis and X-ray diffraction.
- Compounds 2 and 3 showed strong anti-cancer activity against breast and colorectal cancer cells, with effective concentrations ranging from 5.2 to 7.2 μM that were comparable to existing treatments.
- Analysis of protein levels indicated that these compounds promote cancer cell death (apoptosis) by increasing certain proteins (like Bax) and decreasing others (like caspases), suggesting they work through multiple pathways to induce apoptosis.
Background: Job burnout is a stress-related syndrome influenced by both genetic and environmental factors. Poor sleep quality acting as a stressor may lead to job burnout. The oxytocin receptor gene (OXTR) related to stress reactivity may also exert an effect on job burnout.
View Article and Find Full Text PDFbHLH (basic helix-loop-helix) transcription factors play important roles in the abiotic stress response in plants, but their characteristics and functions in tartary buckwheat (), a flavonoid-rich cereal crop with a strong stress tolerance, have not been fully investigated. Here, a novel bHLH gene, designated , was isolated and characterized. Expression analysis in tartary buckwheat revealed that was mainly induced by polyethylene glycol 6000 (PEG6000) and abscisic acid (ABA) treatments.
View Article and Find Full Text PDF[Uncertainty in-statistical-monitor for ICP-AES measurement system by using moving range pooled].
Guang Pu Xue Yu Guang Pu Fen Xi
October 2004
Article Synopsis
- The paper outlines a method for estimating uncertainty in measuring iron (Fe) in metallic silicon using ICP-AES technology.
- It introduces a technique called averaged moving range (MR) pooled in statistical dynamic monitor, which combines quality control and linear fitting.
- The findings aim to simplify the evaluation of measurement uncertainty by effectively managing variance contributions without complicated relationships.