Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity.

Supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery. In this study, four novel biotin-linked calix[4]arenes BPCA1-BPCA4 have been rationally designed to construct nano-complex with doxorubicin. The and assessments reveal that BPCA4-DOX with excellent stability are capable of affording significantly superior anti-tumor activity and lower side effects.

Phytoecdysteroids from Dianthus superbus L.: Structures and anti-neuroinflammatory evaluation.

Six undescribed C-phytoecdysteroid derivatives, named superecdysones A-F, and ten known analogs were extracted from the whole plant of Dianthus superbus L. Their structures were identified by extensive spectroscopy, mass spectrometric methods, chemical transformations, chiral HPLC analysis, and the single-crystal X-ray diffraction analysis. Superecdysones A and B possess a tetrahydrofuran ring in the side chain and superecdysones C-E are rare phytoecdysones containing a (R)-lactic acid moiety, whereas superecdysone F is an uncommon B-ring-modified ecdysone.

Two different one-dimensional Cd(II) halide coordination polymers constructed through bridging carboxylate ligands.

Two cadmium halide complexes, catena-poly[[chloridocadmium(II)]-di-μ-chlorido-[chloridocadmium(II)]-bis[μ2-4-(dimethylamino)pyridin-1-ium-1-acetate]-κ(3)O:O,O';κ(3)O,O':O], [CdCl2(C9H12N2O2)]n, (I), and catena-poly[1-cyanomethyl-1,4-diazoniabicyclo[2.2.2]octane [[dichloridocadmium(II)]-μ-oxalato-κ(4)O(1),O(2):O(1'),O(2')] monohydrate], {(C8H15N3)[CdCl2(C2O4)]·H2O}n, (II), were synthesized in aqueous solution.

Isostructural organic-inorganic hybrid compounds: triethylcholine tribromidocadmate and triethylcholine tribromidomercurate.

In order to search for new anionic architectures and develop useful organic-inorganic hybrid materials in halometallate systems, two new crystalline organic-inorganic hybrid compounds have been prepared, i.e. catena-poly[triethyl(2-hydroxyethyl)azanium [[bromidocadmate(II)]-di-μ-bromido]], {(C8H20NO)[CdBr3]}n, (1), and catena-poly[triethyl(2-hydroxyethyl)azanium [[bromidomercurate(II)]-di-μ-bromido]], {(C8H20NO)[HgBr3]}n, (2), and the structures determined by X-ray diffraction analysis.

Toxic effects of copper on antioxidative and metabolic enzymes of the marine gastropod, Onchidium struma.

The goals of this study were to evaluate the acute and sublethal toxicity of copper (Cu(2+)) on the marine gastropod, Onchidium struma, and to examine the utility of enzymatic parameters as indicators of Cu(2+) exposure. In a semistatic renewal test, the 96-hour median lethal concentration of Cu(2+) for O. struma, 74.