A Novel Strategy for Decoding and Validating the Combination Principles of Huanglian Jiedu Decoction From Multi-Scale Perspective.

Traditional Chinese medicine (TCM) formulas treat complex diseases through combined botanical drugs which follow specific compatibility rules to reduce toxicity and increase efficiency. "Jun, Chen, Zuo and Shi" is one of most used compatibility rules in the combination of botanical drugs. However, due to the deficiency of traditional research methods, the quantified theoretical basis of herbal compatibility including principles of "Jun, Chen, Zuo and Shi" are still unclear.

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development.

The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing great threats to the world in many aspects. Effective therapeutic and preventive approaches including drugs and vaccines are still unavailable although they are in development. Comprehensive understandings on the life logic of SARS-CoV-2 and the interaction of the virus with hosts are fundamentally important in the fight against SARS-CoV-2.

[Influence of Marine Aquaculture Around Coal Power Plant on Mercury Species Change in Auuatic Ecological Environment].

To investigate the influence of marine aquaculture around coal power plant on Hg species change in aquatic ecological environment, the fish farming area in Xiangshan Harbor, Zhejiang province, was studied. The concentrations of different Hg species in sea water collected from marine aquaculture sites (MS) and references sites (RS) were measured. The result showed that the total mercury (THg) concentration in the surface water reached 83.