Fluorescent Polymer Nanocomposites as Novel Drug-Loading and Targeted Delivery Nanocarriers for Glioma Therapy by Modulating ERBB4.

Gliomas are the most common type of tumor in the human central nervous system, characterized by high aggressiveness, elevated mortality, and poor prognosis. Therefore, developing new therapeutic strategies is crucial for improving glioma treatment. Temozolomide (TMZ) is widely used in glioma therapy due to its excellent ability to penetrate the blood-brain barrier.

Biological macro-idea and criterion of osteopathic fracture immobilization in China's traditional Mongolian medicine.

Objective: To investigate the biological macro-idea and criterion of osteopathic fracture immobilization in China's traditional Mongolian medicine.

Methods: Based on biological naturalism regarding the relationship between man and universe (including psychosomatic integration) in osteopathic fracture immobilization in China's traditional Mongolian medicine, we used modern physiopsychological and biomechanical principles and methods to investigate the biological macro-characteristics of humanization, behaviorism, and wholism in "dynamic" fixation of fractures.

Results: Osteopathic fracture immobilization in China's traditional Mongolian medicine is based on the fixation criterion of macro-idea and method as well as on geometry, mechanics, motion, and stress and psychological stability in "non-sheltered fixation" of fractures contained in the life view of nature, regarding the relationship between man and universe (including psychosomatic integration) and on harmony between the limbs and the whole body, between body and function, and between man and nature.

[Neuroendoscope-assisted surgical treatment of spinal dural arteriovenous fistulas].

Objective: To study the utility of neuroendoscope-assisted surgery in the treatment of spinal dural arteriovenous fistulas.

Methods: From November 2008 to November 2010, 8 cases of spinal dural arteriovenous fistulas underwent neuroendoscope-assisted surgical treatment by a hemilaminectomy approach. Retrospective analyses were performed for their clinical manifestations, imaging findings, surgical approaches, postoperative recovery and follow-up profiles.

[The methylation analysis of EMP3 and PCDH-gamma-A11 gene in human glioma].

Objectives: To study the relationship between promoter methylation and mRNA expressions of EMP3 and PCDH-gamma-A11 genes in human glioma, and to analyze the regulation mechanism of promoter methylation in the progression of glioma.

Methods: The promoter methylation of EMP3 and PCDH-gamma-A11 was studied by a methylation specific PCR in 88 primary astrocytoma, 10 normal brain tissues and 2 glioma cell lines. The mRNA expressions were detected by real-time PCR in 30 primary glioma and 10 normal brain tissues.

Macroscopic model for biological fixation and its uncovering idea in Chinese Mongolian traditional osteopathy.

Splintage external fixation in Chinese Mongolian osteopathy is a biological macroscopic model. In this model, the ideas of self-life "unity of mind and body" and vital natural "correspondence of nature and human" combine the physiological and psychological self-fixation with supplementary external fixation of fracture using small splints. This model implies macroscopic ideas of uncovering fixation and healing: structural stability integrating geometrical "dynamic" stability with mechanical "dynamic" equilibrium and the stability of state integrating statics with dynamics, and osteoblasts with osteoclasts, and psychological stability integrating closed and open systems of human and nature.

Clinical presentation and treatment of distal posterior inferior cerebellar artery aneurysms: report on 5 cases.

Background: Aneurysms of the PICA are uncommon. Most of them arise at the PICA origin from the VA, whereas distal PICA aneurysms are exceptional. A retrospective analysis of 457 patients with SAH treated in our hospital found 5 patients with 6 distal PICA aneurysms (approximately 1% of SAHs).