[Study on visual evoked related potentials in young adults of different COMT genotypes by using a numeric working memory task].

Aim: To explore the change of number working memory ability in healthy young adults, a continuous 3-back number working memory task were performed for an hour and 12 Blocks according to different COMT genotypes of young adults.

Methods: 18 different genotype subjects were chosen from 112 healthy young adults, P3 event-related potentials was utilized to observe the relationship between this COMT polymorphism and cortical physiology in a continuous working memory task.

Results: Subjects bearing the Val/Val homozygote had significantly higher mean P3 amplitudes than Val/Met heterozygote (P < 0.

[Role of sGC-cGMP pathway in CO-mediated regulation of respiratory rhythm].

Objective: To identify the role of soluble guanylyl cyclase-cyclic guanine monophosphate (sGC-cGMP) pathway in the carbon monoxide (CO) mediating regulation of respiratory rhythm from the medulla oblongata.

Methods: Medullary slices of newborn Sprague-Dawley rats were prepared for the experiment. The electrophysiological experiment comprised 5 groups (each with 8 slices), each of which were perfused with artificial cerebrospinal fluid (ACSF control group), CO (exogenous CO group), 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (a specific inhibitor of sGC, ODQ group), ODQ+CO (ODQ+CO group), and dimethyl sulfoxide (vehicle of ODQ, DMSO group), respectively.

[Association of polymorphisms of 1772 (C-->T) and 1790 (G-->A) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas].

Objective: To investigate the association of single nucleotide polymorphisms (SNPs) of 1772 (C-->T) and 1790 (G-->A) in exon 12 of hypoxia-inducible factor 1, alpha subunit gene (HIF1A) with hypoxia adaptation in high altitude in Sherpas.

Methods: The blood samples were chosen from 148 Sherpas in Tibet high altitude and 90 Han nationality healthy people in Guangdong province, and from which genomic DNA was extracted. The single nucleotide polymorphisms of 1772(C-->T) and 1790(G-->A) in exon 12 of HIF1A gene were examined by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR).

[Single nucleotide polymorphisms study of surfactant protein A gene between Tibet Sherpas and Guangdong Chinese Hans].

Aim: To investigate the relationship between single nucleotide polymorphisms(SNPs) of surfactant protein A(SP-A) gene of Chinese Han and Sherpas and their adaptation to high altitude hypoxia.

Methods: The genotypes of 90 Chinese Han in Guangdong and 104 Sherpas in Tibet were analyzed by sequence special primer polymerase chain reaction(SSP-PCR) sequencing the surfactant protein A gene.

Results: The frequencies of genotypes and alleles at SP-A1 1544 locus showed no difference between the Sherpas and the Chinese Han (P>0.

[A study on the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia].

Aim: To investigate the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia.

Methods: In the case-control study, the gene polymorphisms of glutathione S-transferases were tested in Tibetan mountaineers and sea-level Han Chinese by multiple-PCR and PCR-RELP.

Results: The frequency of GSTT1 null genotype was significant different between Tibetan mountaineers and sea-level Han Chinese (P < 0.

[Effects of electric stimulation on circadian rhythm of plasma cortisone in soldiers].

Objective: To observe the effects of electric stimulation on the circadian rhythm of plasma cortisone in soldiers.

Methods: Electric stimulation or phototherapy was respectively performed in the popliteal region (behind the knee) of the soldiers at different time points and radio immunal assay was utilized to examine the plasma cortisone concentration.

Results: The plasma cortisone concentration exhibited obvious circadian rhythmicity.