Publications by authors named "Xue-Zhen Zeng"
Establishment and Validation of the Novel Necroptosis-related Genes for Predicting Stemness and Immunity of Hepatocellular Carcinoma Machine-learning Algorithm.
Comb Chem High Throughput Screen
December 2024
Background: Necroptosis, a recently identified mechanism of programmed cell death, exerts significant influence on various aspects of cancer biology, including tumor cell proliferation, stemness, metastasis, and immunosuppression. However, the role of necroptosis-related genes (NRGs) in Hepatocellular Carcinoma (HCC) remains elusive.
Methods: In this study, we assessed the mutation signature, copy number variation, and expression of 37 NRGs in HCC using the TCGA-LIHC dataset.
Identification of Pyroptosis Gene Signature Related Molecular Pattern, Clinical Implication, and Tumor Immunity in Hepatocellular Carcinoma`.
Comb Chem High Throughput Screen
April 2023
Background: Pyroptosis is a novel form of programmed cell death in cancers, which regulates tumor cell invasion, proliferation, and metastasis, thereby affecting the prognosis of cancer patients. However, the role of Pyroptosis-Related Genes (PGs) in Hepatocellular Carcinoma (HCC) remains unclear.
Methods: Somatic mutation, copy number variation, and expression of 41 PGs were assessed in HCC and normal liver from the TCGA dataset.
Article Synopsis
- Complex RNA-RNA interactions are crucial for biological processes, but many remain unknown due to limitations in current mapping methods that mainly capture intramolecular structures.
- A new method called Capture Interacting RNA and Deep Sequencing (CIRDES) was developed to efficiently identify these interactions by capturing RNA and its partners more effectively.
- With CIRDES, researchers successfully detected known and novel RNA interactions, confirming its reliability and potential for comprehensive RNA interactome analysis.