Publications by authors named "Xue-Yu Lv"
Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is effective in regulating mood and high-level cognition in patients with major depressive disorder (MDD). This study aimed to investigate the efficacy of taVNS treatment in patients with MDD and an altered brain topological organization of functional networks.
Methods: Nineteen patients with MDD were enrolled in this study.
Background: Previous studies have found electroacupuncture could improve the clinical symptoms of first-episode major depressive disorder (MDD), but the exact neural mechanism of action needs to be further elucidated.
Methods: Twenty-eight first-episode MDD patients were randomly divided into 14 electro-acupuncture stimulation (EAS) groups and 14 sham-acupuncture stimulation (SAS) groups, and clinical symptoms were assessed and functional magnetic resonance imaging (fMRI) scans were done in both groups. Amplitude of low-frequency fluctuations (ALFF) was used to observe the changes between the pre-treatment and post-treatment in the two groups, and the altered brain areas were selected as region of interest (ROI) to observe the FC changes.
Rumination is a common symptom of major depressive disorder (MDD) and has been characterized as a vulnerability factor for the onset or recurrence of MDD. However, the neurobiological mechanisms underlying rumination and appropriate treatment strategies remain unclear. In the current study, we used resting-state functional magnetic resonance imaging to investigate the effects of body-mind relaxation meditation induction (BMRMI) intervention in MDD with rumination.
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- * The study will involve 90 participants who will be randomly assigned to receive either real or sham taVNS and will undergo a variety of biopsychosocial assessments over a year to measure changes in their depression levels.
- * The clinical trial is ethically approved and aims to publish its findings in peer-reviewed journals to contribute to the understanding and management of MDD.
Article Synopsis
- Music and instruction-guided relaxation (MIGR) is explored as a treatment for major depressive disorder (MDD), but its neural mechanisms are still unclear.
- A study involved MRI scans of 23 MDD patients before and after MIGR and compared them to 23 healthy controls, looking at brain connectivity.
- Results indicated that MDD patients had reduced connectivity in key brain regions compared to the controls, but MIGR might enhance this connectivity, suggesting it could help improve emotional regulation in those with depression.