Publications by authors named "Xue-Ying Yuan"
Article Synopsis
- The study investigates the long-term pollution risks of radioactive nuclides cesium (Cs) and strontium (Sr) in the surface soil of a mining city in China, utilizing various assessment models to analyze contamination levels and health risks.
- Results show that Cs and Sr concentrations are significantly higher in mining areas compared to other regions, but Sr poses little ecological risk and a low non-carcinogenic health risk to humans.
- The sources of Cs are primarily natural, linked to the soil's parent material, while Sr contamination is largely attributed to mining activities, providing crucial information for pollution management in the area.
Background: Hypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation and aggregability are closely related to hypercoagulability in nephrotic syndrome. Monocyte-platelet aggregates (MPAs) have been proposed to represent a robust biomarker of platelet activation.
View Article and Find Full Text PDFBackground: Chronic kidney disease (CKD) is usually considered an immune inflammatory disease. Interaction between platelets and monocytes is associated with immune inflammation. Cross-talk between platelets and monocytes is reflected by formation monocyte-platelet aggregates (MPAs).
View Article and Find Full Text PDFArticle Synopsis
- Podoplanin (PDPN) interacts with the CLEC-2 receptor on platelets, promoting platelet aggregation and increasing the risk of venous thrombosis, especially in inflammatory conditions.
- A study involving 35 nephrotic syndrome patients and 27 healthy volunteers found that PDPN levels were significantly higher in patients, correlating with various markers of hypercoagulability.
- PDPN demonstrated good predictive value for hypercoagulability in nephrotic syndrome with an area under the curve (AUC) of 0.886, indicating that higher PDPN levels (>5.88 ng/ml) significantly increase the risk of thrombosis.
Objective: To explore the potential mechanism of KMUP-1 in the vascular calcification of chronic renal failure (CRF) through mediating NO/cGMP/PKG pathway, and provide novel insights into the CRF treatment.
Methods: CRF rats were treated by KMUP-1 with/without L-NNA (a NOS inhibitor) and then performed by ELISA, alizarin red staining, Von Kossa staining, Masson's trichrome, Sirius red staining and CD3 immunohistochemical staining. Simultaneously, vascular smooth muscle cells (VSMCs) were collected from rats to confirm the effect of KMUP-1 on vascular calcification in vitro via NO/cGMP/PKG pathway.