Mediastinal type B3 thymoma combined with germ cell tumor: cytologic diagnosis.

Primary mediastinal thymoma combined with germ cell tumor (GCT) is extremely rare, and is likely to be misdiagnosed. Here we report a case of mediastinal type B3 thymoma combined with seminoma in which the seminoma component was missed by histologic examination and initially diagnosed by using a pleural effusion sample. The patient was a 46 year old male with chest distress, cough, and supraclavicular lymph node enlargement.

[Impact of C/N Ratio on Nitrogen Removal Performance and NO Release of Granular Sludge CANON Reactor].

To Explore a suitable C/N ratio for efficient nitrogen removal and simultaneously achieving NO release reduction, ammonia-rich wastewater with sodium acetate as an organic carbon source in a granular sludge completely autotrophic nitrogen removal over nitrite (CANON) reactor under different C/N water conditions were studied to determine the reactor's nitrogen removal performance and NO release. The results showed that the total nitrogen (TN) removal rate and the removal load tended to increase gradually with the increase of C/N, ranging from 0 to 2.0.

[Short-cut Nitrification Recovery and Its Transformation into CANON Process in a Biofilm Reactor].

A short-cut nitrification process with modified polyethylene as carrier was operated to investigate the biofilm short-cut nitrification recovery using synthetic inorganic ammonia-rich wastewater as influent at 30℃ ±1℃. The short-cut nitrification was destroyed first by excessive aeration, and it was not built in 83 days under the condition of continuous aeration with DO less than 0.5 mg·L and free ammonia (FA) more than 1.

[Effect of Initial pH on Nitrogen Removal Performance and NO Emission of a Sequencing Batch CANON Reactor].

A completely autotrophic nitrogen removal over nitrite (CANON) reactor with haydite as carrier was operated in a sequencing batch biofilm reactor. The effect of different initial pH on nitrogen removal performance and NO emission was investigated using synthetic inorganic ammonia-rich wastewater as influent at 30℃±1℃. During the experiment, the pH of influent was controlled at 6.

EGFR mutations in non-small cell lung cancer: an audit from West China Hospital.

Objectives: To discover the incidence and characteristics of EGFR mutations in non-small cell lung cancer (NSCLC) in a single, large cohort as a part of routine diagnostic investigations.

Methods: We reviewed EGFR mutations investigated by Amplification Refractory Mutation System (ARMS) PCR (covering 29 known mutations) using DNA samples from FFPE tissue or cell clot specimens in a total of 3894 cases of NSCLC analysed between 2012-2014.

Results: EGFR mutations are preferentially associated with adenocarcinomaand adenosquamous histology, particularly those well to moderately differentiated, and were significantly more common in female than male patients irrespective of histological subtypes.

Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas.

Type B3 thymomas and thymic squamous cell carcinomas have some overlapping histological features, so it is difficult to make the differential diagnosis between these two entities, especially when the biopsy specimen is small. Only a few markers such as CD5 and CD 117 were applied to the differential diagnosis, the purpose of this study is to identify other diagnostic markers to help making the differential diagnosis more accurate. GLUT-1, MUC-1, CD117, CD5, CEA, P63, CK19, CK5/6, CD1a and TdT were evaluated using 16 cases of type B3 thymoma and 20 cases of thymic squamous cell carcinoma.

Thymic epithelial tumors: a clinicopathologic study of 249 cases from a single institution.

The WHO histological classification for thymic epithelial tumors of 2004 edition is widely used, but its prognostic value is still controversial. In the present study we collected 249 Chinese patients with thymic epithelial tumors from West China Hospital of Sichuan University since 1999-2009 to assess the prognosis relating to tumor stages, histological classifications, MG and adjuvant therapy. There were 18 cases of type A (7.

[The clinical value of combining multiple features of CT in discriminating between benign and malignant lung lesions].

Objective: To develop a set of combined criteria of multiple features of chest CT for discriminating between benign and malignant lung lesions.

Methods: Patients whose chest CT showed abnormalities were recruited from the West China Hospital in March and April 2010. The patients were examined with bronchoscopy and the results of CT and pathology were compared.

Cytological differential diagnosis among adenocarcinoma, epithelial mesothelioma, and reactive mesothelial cells in serous effusions by immunocytochemistry.

The objective of the study is to estimate the expression of some antibodies in the metastatic adenocarcinomas, malignant epithelial mesotheliomas, and reactive mesothelial cells in serous effusions and to choose effective panel to the differential diagnosis. Totally 113 effusion cytology samples (80 pleural fluid, 30 ascitic, and 3 pericardial fluid) from 60 cases of metastatic adenocarcinoma (ACA), 18 cases of malignant epithelial mesothelioma (MM), and 35 cases of reactive mesothelium (RM) were included in this study. The cytological diagnoses of these cases were confirmed by histopathology or clinical datas.

Adrenal sarcomatoid carcinoma: a rare case depicted on multi-detector row computed tomography.

Primary adrenal sarcomatoid carcinoma is rare malignant tumor with the characteristics of carcinoma and sarcoma. To date, only one case of primary sarcomatoid carcinoma in the adrenal gland was reported. We present here computed tomography appearance and pathological features of the case with primary adrenal sarcomatoid carcinoma confirmed by pathology.

[Diagnosis of hematolymphoid malignancy by using effusion fluid cytology specimens: a study of 33 cases].

Objective: To study the diagnostic accuracy of hematolymphoid malignancy by using effusion fluid cytology specimens and to evaluate the values of immunocytochemistry for this assay.

Methods: The cytospin preparations/smears and cell block sections of effusion cytology specimens from 33 cases of hematolymphoid malignancy were retrospectively reviewed. Immunocytochemical study was performed.

[Significance of combining detection of E-cadherin, carcinoembryonic antigen, and calretinin in cytological differential diagnosis of serous effusion].

Background & Objective: The morphological characteristics of metastatic adenocarcinoma cells,malignant mesothelioma cells,and reactive mesothelial cells in serous effusions are similar. Sometimes, it is difficult to make a correct diagnosis just based on the cytological characteristics. Although now immunocytochemistry has been widely used in this field,yet only a few antibodies were reported in China,which can't help to make a correct differential diagnosis.