Publications by authors named "Xue-Yin Chen"
Article Synopsis
- Nasopharyngeal carcinoma (NPC) is highly prevalent in Southern China, leading to significant health issues, and current EBV screening methods often result in false positives, suggesting a need for improved screening approaches.
- A Markov model was created using regional health data to compare polygenic risk-stratified screening, which targets individuals based on their 10-year absolute risk, against traditional age-based screening methods.
- Results showed that polygenic risk-stratified screening is more cost-effective for individuals aged 30-54, particularly for men, as it reduces unnecessary procedures and has a higher chance of being cost-effective than the age-based approach.
Previous studies have demonstrated strong associations between host genetic factors and Epstein-Barr virus (EBV) VCA-IgA with the risk of nasopharyngeal carcinoma (NPC). However, the specific interplay between host genetics and EBV VCA-IgA on NPC risk is not well understood. In this two-stage case-control study (N = 4804), we utilized interaction and mediation analysis to investigate the interplay between host genetics (genome-wide association study-derived polygenic risk score [PRS]) and EBV VCA-IgA antibody level in the NPC risk.
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- Radiation-induced brain injury (RBI) significantly impacts the quality of life and survival rates for patients with nasopharyngeal carcinoma (NPC), prompting the need for improved risk stratification tools.
- A large study involving 1189 NPC patients undergoing radiotherapy led to the development of a polygenic risk score (PRS) that effectively identifies individuals at high risk for RBI, with suggested adjusted radiation doses to minimize risk based on genetic predisposition.
- The integration of PRS with clinical factors enhanced prediction accuracy for RBI, indicating that personalized treatment strategies could be developed to optimize patient outcomes.
Article Synopsis
- Large-scale genetic studies found several genetic loci linked to nasopharyngeal carcinoma (NPC), prompting further investigation into biological mechanisms behind these associations.
- A follow-up study involving nearly 7,000 NPC cases and over 10,000 controls identified two new susceptibility loci (9q22.33 and 17q12) and confirmed the role of two previously known loci linked to NPC risk.
- Functional analyses revealed that the genes PHF2 and CDKN2B-AS1 at these loci are crucial for NPC development, with risk alleles affecting their expression levels and consequently promoting NPC cell proliferation.
Article Synopsis
- The study investigates the link between human leukocyte antigen (HLA) molecules that present Epstein-Barr virus (EBV) antigens and the risk of nasopharyngeal carcinoma (NPC).
- Researchers analyzed 455 NPC patients and 463 healthy individuals, using HLA-target sequencing and predictive modeling to assess how EBV peptides bind to different HLA supertypes.
- Results showed that specific EBV peptides have different binding affinities related to NPC risk, with one HLA supertype associated with higher risk and another offering a protective effect, highlighting the complex relationship between EBV, HLA, and NPC development.
Article Synopsis
- Nasopharyngeal carcinoma (NPC) is linked to genetic factors and Epstein-Barr virus infection, making genetic counseling essential for high-risk families.
- A study involving whole-exome sequencing of 502 familial NPC patients revealed rare mutations in known cancer genes and identified 6 new susceptibility genes, with RAD54L showing the highest prevalence.
- Findings suggest that individuals with both rare and common genetic variants face significantly higher NPC risk, paving the way for better risk assessment and prevention strategies for those with a family history of the disease.
Array comparative genomic hybridization (array-CGH), which facilitates to detect unbalanced reciprocal translocation and allows screening aneuploidy for chromosomes, has been repeatedly verified to be valid for diagnosis of translocations in preimplantation human embryos. Currently, the main microarrays used for CGH are bacterial artificial chromosome (BAC)-based arrays. Compared with the BAC-based arrays, oligonucleotide (oligo)-based arrays have a relatively higher resolution and optimal coverage particularly in the subtelomeric regions.
View Article and Find Full Text PDFObjective: To study the value of tumour feeding arteries and the ovarian vein in determining the organ of origin of large pelvic tumours in females using multidetector CT.
Methods: One hundred and thirty patients with 131 pathologically proven tumours (>6.5 cm) were retrospectively reviewed.
We herein report two cases of goats with sexual deformity. They had two systems of reproductive organs and the karyotype analysis showed mosaicism for their sex chromosomes, i.e.
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