Publications by authors named "Xue-Yi Pan"
Protein Z (PZ), a vitamin-K-dependent anticoagulant glycoprotein, is reported to be highly expressed in various malignant tissues and correlated with a poor prognosis in patients with lung cancer. This study aimed to investigate the pathological activity of PZ on lung cancer cell migration, invasion, and metastasis. PZ was assessed by Western blot in three non-small-cell lung cancer cell lines (A549, H1299, and H1975).
View Article and Find Full Text PDF[Establishment and Validation of Immune Risk Score for Predicting Survival of Patients with Acute Myeloid Leukemia].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
April 2022
Objective: To establish an immune gene prognostic model of acute myeloid leukemia (AML) and explore its correlation with immune cells in bone marrow microenvironment.
Methods: Gene expression profile and clinical data of TCGA-AML were downloaded from TCGA database. Immune genes were screened by LASSO analysis to construct prognosis prediction model, and prediction accuracy of the model was quantified by receiver operating characteristic curve and area under the curve.
Purpose: Prediction models for acute myeloid leukemia (AML) are useful, but have considerable inaccuracy and imprecision. No current model includes covariates related to immune cells in the AML microenvironment. Here, an immune risk score was explored to predict the survival of patients with AML.
View Article and Find Full Text PDFPurpose: Adults with T-cell lymphoblastic lymphoma (T-LBL) generally benefit from treatment with acute lymphoblastic leukemia (ALL)-like regimens, but approximately 40% will relapse after such treatment. We evaluated the value of CpG methylation in predicting relapse for adults with T-LBL treated with ALL-like regimens.
Experimental Design: A total of 549 adults with T-LBL from 27 medical centers were included in the analysis.
Article Synopsis
- Researchers developed a gene-expression classifier to predict survival in patients with T-cell lymphoblastic lymphoma (T-LBL), identifying 43 key mRNAs after comparing gene profiles of progressive and progression-free cases.
- The classifier, based on 11 specific genes, was shown to significantly lower progression-free survival, disease-free survival, and overall survival rates for high-risk patients in a training cohort of 169 individuals.
- A prognostic nomogram incorporating the classifier and other factors further improved prediction accuracy for treatment outcomes, indicating that patients with higher scores respond better to the BFM treatment protocol.
We aimed to characterize the clinical significance of epigenetic loss of death-associated protein kinase (DAPK) gene function through promoter methylation in the development and prognosis of lymphoma. PubMed, Web of Science and ProQuest databases were searched for relevant studies. Twelve studies involving 709 patients with lymphoma were identified.
View Article and Find Full Text PDFAs a regulator of coagulation, abnormal Protein Z (PZ) expression may lead to the formation of blood clots in humans. While previous studies have shown that PZ protein is altered in several types of cancer, however, additional observations are needed to understand the complex biology involved. Herein, we investigated local alterations in PZ expression in lung adenocarcinomas by measuring gene and protein expression in both cancerous and normal lung tissues.
View Article and Find Full Text PDF[Advances of treatment for nature killer/T-cell lymphoma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2014
NK/T cell lymphoma (NKTCL) is a rare type of non-Hodgkin's lymphoma, occurs more frequently in Asia and Latin America. In China, NKTCL accounts for 30.1% in T-NHL and is highly related with EBV (Epstein-Barr virus) infection.
View Article and Find Full Text PDF[Expression of Sema4D in patients with cerebral infarction and its clinical significance].
Zhonghua Xue Ye Xue Za Zhi
September 2012
Objective: To explore the expression and clinical significance of Semaphorin4D (Sema4D) mRNA in peripheral blood lymphocyte, Sema4D on platelet surface, soluble Sema4D (sSema4D) in plasma in patients with cerebral infarction.
Methods: Taking 299 patients with cerebral infarction as the case group while 195 healthy adults as the control group. The mRNA expression of Sema4D was detected by Real-time PCR, and Sema4D expression on platelet by flow cytometry, sSema4D by ELISA.
Article Synopsis
- Patients with malignant tumors have significantly lower levels of Protein Z (PZ) and higher levels of coagulation factors FXII:C, FX:C, and FX:Ag compared to healthy individuals, suggesting a hypercoagulable state.
- * The study involved analyzing plasma levels of PZ and various coagulation factors in both tumor patients and healthy controls, revealing a clear correlation between PZ levels and coagulation abnormalities.
- * Lower PZ levels were particularly noted in more advanced cancer stages (III-IV), indicating its potential role as a clinical marker for tumor progression and coagulation risk.
[Clinical significance of protein Z alteration in patients with cardio-cerebral thrombotic diseases].
Zhonghua Xue Ye Xue Za Zhi
November 2004
Article Synopsis
- The study aimed to investigate how protein Z (PZ) levels change in patients with cardio-cerebral thrombotic diseases and their relationship with factor X (FX) levels.
- Results showed that PZ levels were significantly lower in patients with acute ischemic stroke (AIS) and acute myocardial infarction (AMI) compared to healthy individuals, while FX levels were elevated in these patient groups.
- The decrease in PZ was linked to the severity and recurrence of the diseases, with age also playing a role in PZ levels, but no significant correlation was found with gender.