Characterization of CD103 CD8 tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade.

Though therapy that promotes anti-tumor response about CD8 tumor-infiltrating lymphocytes (TILs) has shown great potential, clinical responses to CD8 TILs immunotherapy vary considerably, largely because of different subpopulation of CD8 TILs exhibiting different biological characters. To define the relationship between subpopulation of CD8 TILs and the outcome of antitumor reaction, the phenotype and function of CD103 CD8 TILs in esophageal squamous cell carcinoma (ESCC) were investigated. CD103 CD8 TILs were presented in ESCC, which displayed phenotype of tissue-resident memory T cells and exhibited high expression of immune checkpoints (PD-1, TIM-3).

Neurological manifestations of atrial myxoma: A retrospective analysis.

Atrial myxoma is the most common type of primary cardiac tumor and it is closely associated with stroke in adults. Early diagnosis and treatment of atrial myxomas is essential for the prevention of embolic events. The aim of the present study was to assess neurological complications associated with atrial myxoma.