Effects of N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis.

Background: Hepatitis B cirrhosis (HBC) is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic dysfunction. Although the relationship between certain single probiotics and HBC has been explored, the impact of the complex ready-to-eat N1115 (LP N1115) supplement on patients with HBC has not been determined.

Aim: To compare the changes in the microbiota, inflammatory factor levels, and liver function before and after probiotic treatment in HBC patients.

Risk Factors of Depression Screened by Two-Sample Mendelian Randomization Analysis: A Systematic Review.

Objective: This study explored the potentially modifiable factors for depression and major depressive disorder (MDD) from the MR-Base database and further evaluated the associations between drug targets with MDD.

Methods: We analyzed two-sample of Mendelian randomization (2SMR) using genetic variant depression ( = 113,154) and MDD ( = 208,811) from Genome-Wide Association Studies (GWAS). Separate calculations were performed with modifiable risk factors from MR-Base for 1,001 genomes.

Structures, Biosynthesis, and Bioactivity of Oligomycins from the Marine-Derived sp. FXY-T5.

Oligomycins are potent antifungal and antitumor agents. Mass spectrometry (MS)- and nuclear magnetic resonance (NMR)-based metabolomic fingerprinting analysis of marine-derived actinomycetes in our in-house library provided an oligomycin-producing strain, sp. FXY-T5.

Cinnamaldehyde promotes root branching by regulating endogenous hydrogen sulfide.

Background: Cinnamaldehyde (CA) has been widely applied in medicine and food preservation. However, whether and how CA regulates plant physiology is largely unknown. To address these gaps, the present study investigated the beneficial effect of CA on root branching and its possible biochemical mechanism.

[Effect of Schistosoma japonicum infection on serum lipid status in mice].

Objective: To investigate the effect of Schistosoma japonicum infection on lipid status in mouse serum.

Methods: Twenty-four ICR mice were randomly divided into two groups, fed a high fat diet (HFD) or a normal diet (ND). On the 28th day, 6 mice from each group were infected with double sex cercariae of S.

[Identification of glycosylphosphatidylinositol-anchored protein from Schistosoma japonicum].

Objective: To identify glycosylphosphatidylinositol (GPI) anchored protein of Schistosoma japonicum.

Methods: Based on the gene sequence of Schistosoma mansoni GPI anchored protein Sm200 (GenBank Assess No: XM_002569560.1), bioinformatics analysis was performed to find out its homologous gene sequence in S.

Degradation of microcystin-LR and RR by a Stenotrophomonas sp. strain EMS isolated from Lake Taihu, China.

A bacterial strain EMS with the capability of degrading microcystins (MCs) was isolated from Lake Taihu, China. The bacterium was tentatively identified as a Stenotrophomonas sp. The bacterium could completely consume MC-LR and MC-RR within 24 hours at a concentration of 0.