Euphejolkinolide A, a new -abietane lactone from L. with promising biological activity in activating the autophagy-lysosomal pathway.

A new -abietane diterpenoid, named Euphejolkinolide A (), was isolated from the whole plant of L. Its structure, including absolute configurations, was determined by spectroscopic analyses and was corroborated by single-crystal X-ray diffraction analysis. This new compound was assessed for its activity to induce lysosome biogenesis through Lyso-Tracker Red staining, in which compound could significantly induce lysosome biogenesis.

[An integrative metabolomics and network pharmacology method for exploring bioactive components and preliminary pharmacodynamics in medicinal parts of Harrisonia perforata].

In this paper,metabolomics and network pharmacology were used to investigate the bioactive components of Harrisonia perforata and their possible mechanisms of action. Metabolites in the flowers,fruits,branches,leaves and stalks of H. perforata were analyzed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry.

Three new diterpenoids from .

Three new diterpenoids () (two abietane type diterpenoids and a paralianone type diterpenoid), together with four known compounds () were isolated from the whole plants of . Their structures were elucidated through spectroscopic analysis and physicochemical characteristics. The cytotoxic activities of compounds against five human tumour cell lines were evaluated, however, they were inactive at the concentration of 40 μM.

Sequential invasive-noninvasive mechanical ventilation weaning strategy for patients after tracheostomy.

Background: Because the continuity and integrity of the trachea are likely damaged to some extent after tracheostomy, the implementation of sequential ventilation has certain difficulties, and sequential invasive-noninvasive ventilation on patients after tracheostomy is less common in practice. The present study aimed to investigate the feasibility of invasive-noninvasive sequential weaning strategy in patients after tracheostomy.

Methods: Fifty patients including 24 patients with withdrawal of mechanical ventilation (conventional group) and 26 patients with sequential invasive-noninvasive weaning by directly plugging of tracheostomy (sequential group) were analyzed retrospectively after appearance of pulmonary infection control (PIC) window.