Are contralateral submental artery perforator flaps feasible for the reconstruction of postoperative defects of oral cancer?

Background: We evaluated the clinical applications of the reconstruction of postoperative defects of the oral cavity using contralateral submental artery flaps.

Methods: A retrospective study of 18 patients with postoperative intraoral cancer defects reconstructed with contralateral submental artery perforator flaps between October 2018 and October 2019 in our department was conducted. The defect area, flap size, and complications were evaluated.

Comprehensive assessment of the donor-site of the anterolateral thigh flap: A prospective study in 33 patients.

Background: The anterolateral thigh (ALT) free flap has been an extremely versatile flap. The purpose of this study was to propose comprehensive functional assessments of the donor site.

Methods: A total of 33 ALT flaps were enrolled prospectively.

Proper Choice of Donor Site Veins for Patients Undergoing Free Radial Forearm Flap Reconstruction for the Defects of Head and Neck.

Purpose: The purpose of this study was to analyze the reliability of the deep venous drainage system of the free radial forearm flap.

Materials And Methods: The authors implemented a retrospective cohort study and enrolled patients admitted for the evaluation and management of head and neck tumors with radial forearm flap reconstruction. The primary predictor variables were the donor site veins, including the deep, dual, and superficial venous drainage systems.

A comparison of mandible preservation method and mandibulotomy approach in oral and oropharyngeal cancer: A meta-analysis.

Objective: This study aims to compare the prognoses outcomes of mandibular preservation method (MPM) and the mandibulotomy approach (MLA) in oral and oropharyngeal cancer (OOPC) patients.

Method: We searched PubMed, Web of Science, EMBASE, Chinese BioMedical Literature Database (CBM), Cochrane Library, and clinicaltrials.gov up to September 2016 to identify the studies that compared the prognoses of the MPM versus the MLA in OOPC patients.

Reconstruction of Complex Total Parotidectomy Defect With a Chimeric Anterolateral Thigh Perforator Flap and Vascularized Motor Branch of Femoral Nerve Grafting.

Reconstruction of complex total parotidectomy defects after ablation is always a challenge for surgeons. The surgical technique in reconstructing total parotidectomy defects using an anterolateral thigh (ALT) flap has not been described in detail. This report describes the treatment of a difficult case with a complex total parotidectomy defect.

Transverse cervical vessels as recipient vessels in oral and maxillofacial microsurgical reconstruction after former operations with or without radiotherapy.

Background: The purpose of this study was to investigate the reliability and outcome of using the transverse cervical vessel (TCV) as a recipient vessel for microvascular reconstruction in patients whose vessels in the neck region are unavailable because of previous surgery or radiotherapy.

Methods: Between January 2012 and August 2014, secondary head and neck reconstruction was performed using the TCV as a recipient vessel in eight patients who had undergone previous neck dissection and radiation therapy (n = 5). Five patients had a recurrent carcinoma, one had undergone an operation for scar release and two had been treated surgically for a second primary cancer.

Lack of influence of an XRCC3 gene polymorphism on oral cancer susceptibility: meta-analysis.

Background: To systematically summarize the association between the X-ray repair cross complementing 3 (XRCC3) gene polymorphism and oral cancer susceptibility by meta-analysis.

Materials And Methods: Databases including PubMed, EMbase, CNKI, VIP and WanFang Data were searched to identify case-control studies concerning the association between an XRCC3 gene polymorphism and the risk of oral cancer from the inception to June 2014. Two reviewers independently screened the literature according to the criteria, extracted the data and assessed the quality.

Reconstruction for facial nerve defects of zygomatic or marginal mandibular branches using upper buccal or cervical branches.

Background: Many reconstructive methods for facial nerve defects have been described previously, such as the greater auricular nerve graft, the sural nerve graft, or hypoglossal-facial nerve anastomosis. Herein, we want to instruct a new technique of repairing facial nerve defects of zygomatic or marginal mandibular branches using upper buccal or cervical branches when we have to face segment defects of facial nerve with wide gaps between facial nerve stumps.

Methods: The distal part of the upper buccal or cervical branches with peripheral tissue was removed to repair the defects of zygomatic or marginal mandibular branches.

[Perforator vascular anatomy and clinical application of the anteromedial thigh flap for head and neck reconstruction].

Purpose: A clinical study was undertaken to define the vascular anatomy of anteromedial thigh perforator flap (AMT) and evaluate the outcomes of the flap in head and neck reconstruction.

Methods: The sizable perforators of AMT flaps and their origins were prospectively explored in 54 patients. For each patient, we recorded the sizable perforators' location, diameter, source vessel, numbers and anatomical types.

Modified incision design for submental flap: an excellent design method for the reconstruction of a defect after head and neck tumor resection.

Background: The usage of submental flap is a good method for head and neck reconstruction, but it has some risk also, such as anatomical variations and surgical errors. In this article, we present a modified incision design for the submental flap.

Methods: We designed a modified submental flap incision method based on the overlap of the incision outline of the submental flap, platysma myocutaneous flap and infrahyoid myocutaneous flap.

Yu's flap for lower lip and reverse Yu's flap for upper lip reconstruction: 20 years experience.

Reconstruction of defects of the lip caused by cancer with its requirements of a complicated anatomical structure, important physiological function, and acceptable cosmetic result, is a challenge for oral and maxillofacial and plastic surgeons. A method that combines rotation and advancement flaps was described by Yu in 1989 for the reconstruction of defects of the lower lip. In our department between January 1992 and December 2012, 8 patients had reverse Yu flaps for the reconstruction of upper lip defects and 56 patients had classic Yu flaps for lower lip defects.

[Expression and significance of Runx3 in salivary adenoid cystic carcinoma].

Purpose: To investigate the association between Runx3 expression and progression of salivary adenoid cystic carcinoma(SACC).

Methods: The expression of Runx3 was examined in 4 pairs of primary SACC and adjacent salivary gland tissues from the same patient, using real-time PCR and Western blot. Furthermore, the Runx3 protein expression was analyzed in 65 clinicopathologically characterized SACC cases by immunohistochemistry.

[Investigation of rat submandibular gland cells and antheraea pernyi silk fibroin films co-culture in vitro].

Purpose: In this study, the morphology, attachment, growth and secretion of rat submandibular gland cells (RSMGs) cultured on the antheraea pernyi silk fibroin(ApSF) films were observed in vitro.

Methods: RSMGs were seeded on ApSF scaffolds and bombyx mori silk fibroin (BmSF) scaffolds respectively. RSMGs which were seeded on tissue culture plastic were treated as a negative control group.

[Implant-supported overdenture after pectoralis major myocutaneous flap reconstruction of tongue/floor of the mouth cancer:a case report].

Patients with oral cancer, undergoing ablative surgery, were left with severe deformities and dysfunction. Although the defect can be repaired by flap transplantation, there were still difficulties to restore normal oral structure and function of the oral cavity. In these instances, rehabilitation of mastication and occlusion is of the utmost importance.

[Perforator-based chimeric anterolateral thigh flap for head and neck reconstruction after en bloc resection].

Purpose: To discuss and report the operative techniques for harvesting perforator-based chimeric flap in anterolateral thigh region and the advantages for head and neck reconstruction after en bloc resection.

Methods: A retrospective review was performed of perforator-based chimeric anterolateral thigh (ALT) flap for head and neck reconstruction since December of 2007 to March of 2011. 66 perforator-based chimeric flaps were harvested including a skin paddle and a muscular flap supplied by one mother pedicle-descending branch of lateral circumflex femoral artery(d-LCFA).

Reconstruction for defects of the lower lip after tumor ablation.

Background: The lip carcinoma, which frequently affects the lower lip, is one of the most common cancers of the head and neck region composing 25% to 30% of all oral cancers. The accepted method of therapy for lip cancer is surgical excision and reconstruction. The repair should satisfy 2 fundamental requirements: to achieve appropriate aesthetic quality and to conserve labial function.

[Experimental study on rat submandibular gland cell and silk fibroin-chitosan in vivo].

Objective: To evaluate the feasibility of the tissue engineered submandibular gland constructed in vivo based on submandibular gland cells and silk fibroin-chitosan (SFCS).

Methods: Submandibular gland cells were obtained and purified. The second generation cells labeled by 5'-BrdU were seeded on SFCS(5 mm × 5 mm × 5 mm).

Clinical anatomical study and evaluation of the use of the free anteromedial thigh perforator flaps in reconstructions of the head and neck.

The anteromedial thigh (AMT) perforator flap is usually thin, pliable, and nearly hairless, making it particularly suitable to repair defects of the head and neck. We studied the topography and outcomes of AMT perforator flaps in such defects after excision of tumours. We retrospectively reviewed the casenotes of 11 consecutive patients who had had reconstructions of the head and neck with the initial intent of using an AMT perforator flap from January 2010 to July 2011.

[Anteromedial thigh perforator flap an ideal alternative flap for anterolateral thigh flap without suitable perforator].

Purpose: To find a reliable alternative flap with minimal donor site morbidity for anterolateral thigh flap (ALT) without suitable perforator.

Methods: From December 2007 to February 2011, 2 of 64 patients underwent tongue and floor of mouth reconstruction with an anteromedial thigh flap with the initial intent of using an anterolateral thigh flap. One was a perforator flap and the size was 7cm×4cm , the other was a perforator-based chimeric flap including a slender of rectus femoris island and a 14cm×6cm skin paddle.

[Clinical application of unimportant branches of facial nerve to repair important ones].

Purpose: To study the feasibility and clinical effect of repairing important branches of facial nerve (zygomatic and marginal mandibular branches) with unimportant ones (upper buccal and cervical branches).

Methods: The defect of zygomatic and marginal mandibular branches was repaired with upper buccal and cervical branches, respectively. After the length of facial nerve defect was measured, the distal part of the upper buccal and cervical branches with peripheral tissue was used to repair the defect.

[The development and collagen ingredients analysis of submandibular gland acellular matrix].

Purpose: To develop submandibular gland acellular matrix and observe its structure and analyze its histological ingredients.

Methods: The fresh submandibular glands of SD mice were cell-extracted by chemical detergent and histological ingredients were analyzed by immunohistochemistry.

Results: Submandibular gland cells disappeared, matrix ingredients appeared network structure under microscopy.

[Effects of epidermal growth factor on calciumion and cAMP in the ductal cells of submandibular glands].

Purpose: To study the effects of EGF on Ca(2+) and cAMP in the ductal cells of rat SMG.

Methods: Fluorometric technique and radioimmunological technique were used to investigate the dynamic changes of Ca(2+) and cAMP in the ductal cells. The data were analysed statistically by t test.

[The development and ultrastructure study of acellular submandibular gland scaffold].

Purpose: To develop nature acellular submandibular gland scaffold materials and observe its ultrastructures.

Methods: The fresh submandibular glands of SD rats were cell-extracted by chemical detergent and observed with transmission and scanning electron microscope.

Results: Submandibular gland cells were dissolved and destroyed under transmission electron microscope.