Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells.

A series of fluorescent thiazole-pyrazoline derivatives was synthesized and their structures were characterized by H NMR, C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer (NSCLC) A549 cells in a dose- and time-dependent manner in vitro and inhibit tumor growth in vivo. The structure-activity relationship (SAR) of the compounds was analyzed.

[IHA detection results of outpatients in schistosomiasis clinic, 2005-2014].

Objective: To understand the changes of positive rates of IHA detections of outpatients in schistosomiasis clinic.

Results: The data of IHA detections of outpatients in schistosomiasis clinic in Hubei Provincial Center for Disease Control and Prevention were collected and analyzed statistically from 2005 to 2014.

Results: A total of 7 113 outpatients were detected by IHA test, and 547 of them were positives with a positive rate of 7.

[Establishment of archives of Schistosoma japonicum antibody indirect hemagglutination tests].

Objective: To establish written and electronic archives of Schistosoma japonicum antibody indirect hemagglutination (IHA) tests.

Methods: In the process of schistosomiasis screening by IHA, the written records, electronic records, and serum sample bank were combined to make comprehensive archives.

Results: The S.

Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth.

A series of novel 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives was synthesized. The structures of compounds were characterized by (1)H NMR, IR, and MS. Moreover, representative crystal structure was determined by X-ray diffraction analysis.