A meta-analysis of PDE-gene polymorphism and cerebral infarction risk.

Previous studies identified that phosphodiesterase 4D () gene polymorphism might be associated with cerebral infarction or ischemic stroke, and hemorrhagic stroke in human populations. However, as yet, no meta-analysis has revealed any detailed association. We retrospectively reviewed studies regarding the relationship of gene polymorphism with ischemic stroke (IS) published during the period January 2003 to September 2012.