Publications by authors named "Xue-Wen Fang"
Nasopharyngeal carcinoma (NPC) is prevalent in Southern China. Unfortunately, current treatments encounter multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp), resulting in the efflux of chemotherapy drugs, is one of the significant mechanisms causing MDR.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the relationship between neutrophil-to-lymphocyte ratio (NLR) and short-term outcomes in patients with mild acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT), specifically looking at whether a high NLR correlates with poorer outcomes.
- - Researchers analyzed data from 192 patients with mild AIS, finding that 26.6% had a high NLR at admission, and those with higher NLRs were more likely to experience poor outcomes both at discharge and three months later.
- - The findings suggest that a high NLR on admission could serve as a significant predictor of poor short-term outcomes for these patients, highlighting its potential as a useful clinical marker. *
Background: Susceptibility weighted imaging (SWI) provides an approximate assessment of tissue perfusion and shows prominent hypointense cortical veins in the ischemic territory because of the increased concentration of deoxyhemoglobin. We aimed to evaluate whether asymmetrical prominent cortical vein sign (APCVS) on SWI can predict early neurological deterioration (END) in acute ischemic stroke patients with severe intracranial arterial stenosis or occlusion (SIASO).
Methods: One hundred and nine acute ischemic stroke patients with SIASO who underwent SWI were retrospectively recruited.
Introduction: To assess whether the asymmetrical cortical vessel sign (ACVS) on susceptibility-weighted imaging (SWI) could predict 90-day poor outcomes in anterior circulation acute ischemic stroke (AIS) patients treated with recombinant tissue plasminogen activator (r-tPA).
Methods: Clinical data of consecutive patients with anterior circulation AIS treated with r-tPA were retrospectively analyzed. Clinical variables included age, sex, vascular risk factors, NIHSS score, onset to treatment time, and initial hematologic and neuroimaging findings.
Anxiety is prevalent after a stroke. The pathophysiological mechanisms underlying the development of poststroke anxiety (PSA) remain unclear. The aim of this study was to investigate the clinical and neuroimaging risk factors for development of PSA and examine the effects of PSA on activities of daily living (ADL) and quality of life (QOL) in Chinese patients with ischemic stroke.
View Article and Find Full Text PDFIntracranial Atherosclerosis and Poststroke Depression in Chinese Patients with Ischemic Stroke.
J Stroke Cerebrovasc Dis
April 2016
Background: Intracranial atherosclerosis (ICAS) is a common etiology of ischemic stroke in Chinese patients, probably leading to regional hypoperfusion in the brain. The purpose of this prospective study was to investigate the association between ICAS and poststroke depression in Chinese patients with ischemic stroke.
Methods: During the study period, a total of 569 patients aged between 40 and 80 years with acute ischemic stroke were consecutively admitted and screened.
Background: Fatigue is a common problem in ischemic stroke survivors. The mechanisms of poststroke fatigue are uncertain yet. The effects of it on functional status have rarely been studied.
View Article and Find Full Text PDFObjectives: The aim of the present study was to explore the magnetic resonance imaging correlates of the performance of instrumental activities of daily living (IADL) in patients with Alzheimer's disease combined with cerebrovascular disease.
Methods: A total of 66 patients with Alzheimer's disease combined with cerebrovascular disease formed the study sample. Two regression models were constructed to find correlates of IADL.