Publications by authors named "Xue-Wan Ge"
Biomed Pharmacother
November 2022
Article Synopsis
- Xin-Ji-Er-Kang (XJEK), a traditional Chinese medicine, shows protective effects against heart diseases, particularly in myocardial ischemia-reperfusion (MIR) injury, but its specific components and mechanisms remain unclear.
- A study analyzed key compounds in XJEK and their effects on MIR injury using high-resolution mass spectrometry and bioinformatics, along with testing in mice over six weeks, focusing on cardiac function and apoptosis levels.
- Results indicated that matrine, found in Sophora flavescens alkaloids, is the main active ingredient in XJEK, which enhances heart function and reduces cell death by activating the JAK2/STAT3 signaling pathway.
Front Pharmacol
August 2022
Article Synopsis
- Scientists tested a treatment called Xin-Ji-Er-Kang (XJEK) on mice to see if it helps prevent heart damage after a heart attack, which hadn't been looked at before.
- They created heart injury in mice and found that XJEK improved the heart's function and reduced inflammation and other harmful effects caused by the injury.
- This study showed for the first time that XJEK can protect the heart from damage and suggests it could be useful in future research and treatments for heart problems.
