Cerebellar injury induced by cadmium via disrupting the heat-shock response.

Cadmium (Cd) is a food contaminant that poses serious threats to animal health, including birds. It is also an air pollutant with well-known neurotoxic effects on humans. However, knowledge on the neurotoxic effects of chronic Cd exposure on chicken is limited.

Selenoprotein W as a molecular target of d-amino acid oxidase is regulated by d-amino acid in chicken neurons.

Selenoprotein W (SelW) is an important member of the avian selenoprotein family. It is well known for its important role in protecting neurons from oxidative stress during neuronal development. d-Amino acid (d-serine), as a neurotransmitter in the central nervous system (CNS), can mediate neurotoxicity.

Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis.

Cadmium (Cd) is a ubiquitously distributed trace metal and environmental pollutant that is highly toxic to liver. Selenium (Se) may provide chemoprotection against Cd-induced cytotoxicity by augmenting the cellular antioxidant capacity. However, the mechanism of Se chemoprotection against Cd-induced hepatotoxicity is unclear.

Selenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (Gallus gallus).

Selenophosphate synthetase (SPS) is essential for selenoprotein biosynthesis. In two SPS paralogues, SPS1 was only cloned from a cDNA library prepared from avian organ. However, the biological function of SPS1 in chicken central nervous system (CNS) remains largely unclear.

Bis(2-amino-6-methyl-1,3-benzothia-zole-κN)bis-(4-nitro-benzoato-κO)zinc.

In the title mononuclear complex, [Zn(C(7)H(4)NO(4))(2)(C(8)H(8)N(2)S)(2)], the Zn(II) atom is coordinated by two N atoms from two 2-amino-6-methyl-1,3-benzothia-zole and by two carboxylate O atoms from two 4-nitro-benzoate ligands, adopting a slightly distorted tetra-hedral coordination geometry. In the crystal, inter-molecular N-H⋯O hydrogen bonds between the amino group of 2-amino-6-methyl-1,3-benzothia-zole and the carboxyl-ate group of 4-nitro-benzoate link these discrete mononuclear units into a one-dimensional supra-molecular chain extending parallel to [100].