Publications by authors named "Xue-Song Gu"
A protocol for highly enantioselective hydrogenation of racemic α-arylamino lactones with catalysis by site-specifically modified chiral spiro iridium complexes has been developed. With the optimized catalyst, racemic α-arylamino-γ-lactones and α-arylamino-δ-lactones could be hydrogenated to the corresponding chiral 2-amino diols with good to excellent enantioselectivities.
View Article and Find Full Text PDFArticle Synopsis
- This study investigated how the shape and characteristics seen on CT scans relate to the survival outcomes of patients with stage I non-small cell lung cancer (NSCLC).
- In total, 124 patients were analyzed, and the results showed a 5-year survival rate of about 67.74%, with better outcomes seen in earlier tumor stages like T1a and T1b.
- Key findings identified T2a stage and pleura thickening/indentation as significant independent risk factors linked to poorer survival prognosis for patients with stage I NSCLC.
A highly efficient Ir-catalyzed asymmetric hydrogenation of racemic β-keto lactams via dynamic kinetic resolution (DKR) for the synthesis of optically active β-hydroxyl lactams has been described. With the Ir-SpiroSAP catalyst, a series of racemic β-keto lactams including β-keto γ-, δ-, and ε-lactams were hydrogenated to chiral β-hydroxy lactams in high yields (87-99%) with excellent enantio- and diastereoselectivity (83-99.9% ee, syn/anti: 97:3->99:1) at low catalyst loading under mild reaction conditions.
View Article and Find Full Text PDF