Investigation of the relationship between Body Mass Index and epilepsy.

Objective: To examine the clinical characteristics and influencing factors among epilepsy patients with varying Body Mass Index (BMI), and to propose new approaches for the prevention and treatment of epilepsy.

Methods: A total of 250 adult patients, newly diagnosed with epilepsy and not yet treated with antiepileptic drugs at the First Affiliated Hospital of Dali University between January 2017 and December 2022, were randomly selected as the experimental group. Additionally, 250 healthy individuals from the same period served as the control group to investigate the relationship between BMI and epilepsy.

The relationships between obesity and epilepsy: A systematic review with meta-analysis.

Objective: There is ongoing debate regarding the association between epilepsy and obesity. Thus, the aim of this study was to examine the correlation between epilepsy and obesity.

Method: This study adhered to the PRISMA guidelines for systematic reviews and meta-analyses.

The expression of ProBDNF and its high affinity receptor P75NTR in the neurons of emotion-related brain regions of post-stroke depression rats.

Objective: To investigate the expression of the precursor of brain-derived neurotrophic factor (proBDNF) and its high-affinity receptor p75NTR in neurons of emotion-related brain areas (prefrontal cortex, hippocampus, and amygdala) in rats with post-stroke depression (PSD), and to explore the expression levels of proBDNF and p75NTR in neurons of emotion-related brain areas by injecting tissue plasminogen activator (t-PA) into the lateral ventricle of PSD rats, this significantly improved the stress-induced depression-like behavior,thus further validating the above results.

Methods: Rats were randomly divided into four groups: a normal control group (n = 8), a depression group (n = 8), a stroke group (n = 8), and a PSD group (n = 8). The rat model of stroke was established by thread embolism, and the PSD animal model was induced by chronic unpredictable mild stress (CUMS) and solitary feeding.

Risk analysis of depression among adult patients with epilepsy of different sex: a retrospective single-center study from China.

Objective: To determine sex differences in the prevalence of depression and assess the risk factors for depression among adult patients with epilepsy from the Dali area of China.

Methods: We retrospectively analyzed the clinical data of adult patients with epilepsy who visited the First Affiliated Hospital of Dali University from January 2017 to January 2022. Patient Health Questionnaire-9 was used to assess depressive symptoms in patients with epilepsy.