Publications by authors named "Xue-Ming Yao"
Background/purpose(s): The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut virome in arthritis patients, including osteoarthritis (OA) and gouty arthritis (GA), requires further investigation.
Methods: We employed virus-like particle (VLP)-based metagenomic sequencing to analyze gut viral community in 20 OA patients, 26 GA patients, and 31 healthy controls, encompassing a total of 77 fecal samples.
Article Synopsis
- Hydroxychloroquine (HCQ) is commonly used to treat autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus but can lead to serious side effects, such as skin hyperpigmentation and eye damage.
- A case study highlighted a 65-year-old woman who developed blurred vision and hyperpigmentation after three years on HCQ for rheumatoid arthritis, leading to a diagnosis of drug-induced skin pigmentation and macular lesions.
- Following the discontinuation of HCQ and switching to iguratimod treatment, her skin pigmentation improved, although her vision issues persisted, stressing the importance of monitoring and regular eye exams for patients on HCQ.
Although the pathogenesis of rheumatoid arthritis (RA) remains unclear, an increasing number of studies have confirmed that pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) is an important factor affecting the progression of RA. Periplogenin (PPN) is a natural cardiac glycoside; reportedly, it exerts anti-inflammatory and analgesic effects in diseases by inhibiting cell growth and migration. This study aimed to determine the effect of PPN on the growth, migration, and invasion of RA-FLS and the potential mechanism of pyroptosis regulation.
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- This study aimed to compare the effectiveness and safety of adalimumab (ADA) with a herbal remedy called Tripterygium wilfordii (TwHF) against ADA combined with methotrexate (MTX) for patients with rheumatoid arthritis (RA) who did not respond well to MTX.
- Conducted with 64 RA patients, the trial included a treatment group (ADA + TwHF) and a control group (ADA + MTX), monitoring outcomes over 24 weeks for low disease activity and remission rates.
- Results showed no significant differences in efficacy or safety between the two treatment options, indicating that TwHF could be a viable alternative for RA patients who cannot
Rationale: Acute generalized exanthematous pustulosis (AGEP) is a serious adverse skin reaction characterized by the rapid appearance of densely distributed, small, sterile pustules with erythema. However, its pathogenesis is not fully understood. Hydroxychloroquine is widely used for the treatment of autoimmune diseases.
View Article and Find Full Text PDFIntroduction: Acute generalized exanthematous pustulosis (AGEP) is a rare condition characterized by superficial pustules following drug ingestion or infection. Currently, there is no clear link between rheumatism and AGEP. It has been described that hydroxychloroquine (HCQ) is a rare cause of acute generalized epidermal necrolysis (AGEP).
View Article and Find Full Text PDFDermatomyositis (DM) is a poorly prognostic autoimmune disease the pathogenesis of which is multifactorial and not clearly defined. DM may be influenced by genes, environment, and immunity. The typical manifestations of DM are Gottron rash, heliotrope rash, rash on the shoulders and buttocks, erythema around fingernails, excessive keratosis of the epidermis, mechanic's hands, and interstitial lung disease (ILD), among others.
View Article and Find Full Text PDFJinwujiangu Capsule Treats Fibroblast-Like Synoviocytes of Rheumatoid Arthritis by Inhibiting Pyroptosis via the NLRP3/CAPSES/GSDMD Pathway.
Evid Based Complement Alternat Med
November 2021
Jinwujiangu capsule (JWJGC) is a traditional Chinese medicine formula used to treat rheumatoid arthritis (RA). However, whether its mechanism is associated with pyroptosis remains unclear. In this study, the ability of JWJGC to inhibit the growth of fibroblast-like synoviocytes of RA (RA-FLS) through pyroptosis was evaluated.
View Article and Find Full Text PDF[Effects of Jinwu Jiangu recipe on IL-17/STAT3 signals in rheumatoid arthritis synoviocytes].
Zhongguo Zhong Yao Za Zhi
February 2018
Article Synopsis
- The study investigated how the Jinwu Jiangu recipe total extract affects IL-17/STAT3 signaling in rheumatoid arthritis synovial fibroblasts (RASF).
- The primary RASFs were treated with varying doses of the extract and compared to control groups, analyzing gene expression and protein activity through PCR and Western blot assays.
- Results indicated that the Jinwu Jiangu extract significantly reduced mRNA and protein levels of IL-17R and pSTAT3, particularly at higher doses, suggesting its potential therapeutic effects on rheumatoid arthritis.
[Effect of Jinwu Jiangu Recipe on Expressions of NF-kappaB and IL-17 in Collagen Induced Arthritis Model Rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
May 2016
Objective: To explore the effect of Jinwu Jiangu Recipe (JJR) on the expression of synovial cells' nuclear factor-kappaB (NF-kappaB) and serum interleukin 17 (IL-17) in collagen induced arthritis (CIA) rats.
Methods: Totally 60 Wistar rats were randomly divided into 6 groups, i.e.
[Effect of jiedu huayu recipe containing serum on the expressions of survivin and NF-kappaB of K562/A02 cell apoptosis by].
Zhongguo Zhong Xi Yi Jie He Za Zhi
August 2011
Objective: To study the effect of Jiedu Huayu Recipe containing serum on the expressions of survivin gene of leukemia K562/A02 cell apoptosis and the expression of nuclear factor kappa B (NF-kappaB).
Methods: K562/A02 cells were divided into six groups. An equal volume of calf serum, rabbit serum, high, middle, and low dose Jiedu Huayu Recipe containing serum, and interferon was respectively added.