Publications by authors named "Xue-Ling Kang"
Article Synopsis
- Cancer stem cells (CSCs) significantly contribute to colorectal cancer (CRC) development and treatment resistance, making them important targets for research.
- This study focuses on the expression of two markers, DCLK1 and Lgr5, in CRC patients to evaluate their potential as prognostic indicators for disease outcomes.
- Results show that high levels of DCLK1 and Lgr5 are linked to poorer survival rates and may indicate DCLK1 as a key factor for predicting CRC recurrence and overall patient survival.
Renal cell carcinoma (RCC) accounts for approximately 3% of all new cancer cases. Although the classification of RCC is based mainly on histology, this method is not always accurate. We applied comparative genomic hybridization (CGH) to determine genomic alterations in 46 cases of different RCC histological subtypes [10 cases of clear cell RCC (CCRCC), 13 cases of papillary RCC (PRCC), 12 cases of chromophobe RCC (CRCC), 9 cases of Xp11.
View Article and Find Full Text PDFUnclassified renal cell carcinoma (URCC) is a rare variant of RCC, accounting for only 3-5% of all cases. Studies on the molecular genetics of URCC are limited, and hence, we report on 2 cases of URCC analyzed using comparative genome hybridization (CGH) and the genome-wide human exon GeneChip technique to identify the genomic alterations of URCC. Both URCC patients (mean age, 72 years) presented at an advanced stage and died within 30 months post-surgery.
View Article and Find Full Text PDF[Notch1 mRNA and protein expression in human breast cancer and normal mammary gland tissues].
Zhonghua Bing Li Xue Za Zhi
December 2009
Objective: To explore the Notch1 mRNA and protein expression in human breast cancers and normal mammary tissues, and their relationship with the clinical indicators of breast cancers were analyzed.
Methods: Notch1 gene of human breast invasive ductal carcinoma (IDC) and normal mammary gland tissues were amplified by RT-PCR, and the expression of Notch1 protein was detected by immunohistochemical Streptavidin-Biotin Complex (SP) stain in 60 IDC, 30 ductal carcinoma in situ (DCIS) and 60 normal mammary tissues.
Results: Notch1 gene of human IDC and normal mammary tissues both could express in a transcription level; the positive rates of Notch1 protein expression in normal mammary tissues and DCIS were 55% and 70%.