Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy.

Esophageal cancer (ESC) is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract. Although the exact pathogenesis of ESC has not been fully elucidated, excessive oxidative stress is an important characteristic that leads to the development of many cancers. Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs, which alters the growth and proliferation of ESCs and promotes their metastasis.

Berberine: An inspiring resource for the treatment of colorectal diseases.

Colorectal cancer is a prevalent malignant tumor with a complex and diverse pathogenesis. In recent years, natural products have shown promising application prospects as sources of anticancer drugs. BBR, a class of benzoquinoline alkaloids extracted from various plants, is widely used in disease treatments owing to its pharmacological activities, including antibacterial, anti-inflammatory, antioxidant, anticancer, and anti-angiogenesis properties.

Doxycycline vs Placebo at 12 Weeks in Patients With Mild Thyroid-Associated Ophthalmopathy: A Randomized Clinical Trial.

Importance: Mild thyroid-associated ophthalmopathy (TAO) negatively impacts quality of life, yet no clinical guidelines for its treatment are available. Existing evidence supports the use of doxycycline in treating mild TAO.

Objective: To evaluate the short-term (12 weeks) efficacy of doxycycline in treating mild TAO.

Reconstruction of complex orbital fracture with titanium implants.

Aim: To evaluate the effectiveness and safety of complex orbital fracture reconstruction with titanium implants.

Methods: A retrospective review of 46 patients treated with complex orbital fractures reconstruction using titanium implants from January 2005 to December 2008 was conducted. The following data were recorded: age, gender, mechanism of injury, preoperative and postoperative orbital CT, visual acuity, diplopia, ocular motility and Hertel exophthalmometer.

Transcranial surgery through pterional approach for removal of cranio-orbital tumors by an interdisciplinary team of nurosurgeons and ophthalmologists.

Aim: To investigate the specialty of transcranial surgery through pterional approach for removal of cranio-orbital tumors, introduce the ophthalmological experiences of entering the orbit to reduce the incidence rate of associated complications of this operation.

Methods: We performed a retrospective analysis of a series of 37 cases involving patients who underwent transcranial surgery through pterional approach for treatment of cranio-orbital tumors in our department in the past 8 years. Pterion approach craniotomy was performed to all patients.

[Effects of LPS-induced inflammation on differentiation of orbital pre-adipocytes in thyroid-associated ophthalmopathy].

Objective: To investigate the effects of lipopolysaccharide (LPS)-induced inflammation on the differentiation of orbital pre-adipocytes in thyroid-associated ophthalmopathy (TAO) and to explore the mechanism of orbital adipose proliferation in TAO.

Methods: Orbital adipose tissues were obtained from patients with TAO undergoing orbital decompression surgery. The orbital fibroblasts cultured from orbital adipose tissues were divided into group A and group B.

Role of unc5b in retinal neovascularization in mice with oxygen-induced retinopathy.

Aim: To explore the role of unc5b in retinal neovascularization in murine oxygen-induced retinopathy (OIR).

Methods: On postnatal 7(P7), C57BL/6J mice were exposed to 75%±2% oxygen for 5 days. On postnatal 12(P12), the mice were brought back to the room air (21% oxygen) to induce retinal neovascularization.

[Transcranial operation for cranio-orbital communicating tumors and its complications].

Objective: To investigate the procedure of transcranial operation via pterional approach for cranio-orbital communicating tumors, to improve surgery skills, to summarize the incidence of main complications and to discuss tips for avoiding damage of the normal orbital tissues.

Methods: Pterional approach was adopted for the operation. After the medial orbital wall or lateral orbital wall was bitten with rongeur and the orbital roof was removed, the extraocular muscles at orbital apex were separated and protected.

[Histopathologic and ultrastructural study of extraocular muscles in thyroid associated ophthalmopathy].

Objective: To investigate histopathologic and ultrastructural changes of extraocular muscles (EOM) in thyroid associated ophthalmopathy (TAO).

Methods: Twelve EOM specimens from 11 patients with TAO were observed. Each of the specimen was stained with HE and observed by light microscope,and then was sectioned with ultrathin method and observed by transmission electronic microscope.

[Characteristics of ocular adnexal non-Hodgkin lymphoma].

Objective: To investigate the clinical manifestation and pathological features of primary ocular adnexal non-Hodgkin lymphoma.

Methods: Data of 18 patients with biopsy-proven ocular adnexal non-Hodgkin lymphoma at Xiangya hospital were reviewed.The disease site, clinical manifestation,imaging and pathological features of the tumor were summarized.

[Suture-fixation of foldable Akreos intraocular lens by two-point on sclera and four-haptic of the lens].

Objective: To evaluate the therapeutic efficacy of suture-fixation of foldable intraocular lens for non-posterior-capsular aphakia.

Methods: Akreos intraocular lens (from Bausch-Lamb Company) were selected for operation in aphakia with non-posterior-capsule or less capsule supporting intraocular lens. Complications and visual acuity were observed.

[Transconjunctival surgical cryoextraction of introconal orbital cavernous hemangiomas].

Objective: To evaluate the Methods , complication and operative skill in transconjunctival surgical cryoextraction of intraconal orbital cavernous hemangioma.

Methods: Among the 41 patients diagnosed as orbital cavernous hemangioma preoperatively, 36 suitable for the condition were treated with the operation. The operation time was recorded, and the complications were observed during and after the operation.

[Cell surface antigen expression of orbital preadipocytes between patients with thyroid-associated ophthalmopathy and healthy adults].

Objective: To study the cell surface antigen expression of orbital preadipocytes between patients with thyroid-associated ophthalmopathy (TAO) and healthy adults.

Methods: Tissue culture Methods were used in the cell culture of orbital preadipocytes in patients with TAO and healthy adults. Flow cytometry was used to analyze the expression of CD29, CD44, CD49d, and HLA-DR in these 2 cells.

[Clinical effects of the mixture of 5-fluorouracil and triamcinolone acetonide on capillary hemangioma of eyelid].

Objective: To evaluate the clinical effects of the mixture of 5-fluorouracil (5-FU) and triamcinolone acetonide on capillary hemangioma of eyelid.

Methods: One hundred and one patients with capillary hemangioma of eyelid were divided into Group A and Group B: Group A was injected with triamcinolone acetonide, and Group B was injected the mixture of 5-FU and triamcinolone acetonide.

Results: The cure rate was 68.

[Cataract extraction through no-sitch small incision combined with intraocular lens implantation].

Objective: To investigate the method and clinical effect of cataract extraction through no-sitch small incision combined with intraocular lens (IOL) implantation.

Methods: Ninety-three cases of cataract were divided into two groups at random. Cataract extraction combined with IOL implantation through no-sitch small incision was performed on one group, and cataract extraction combined with IOL implantation through conventional large incision was performed on the other group as controls.