Publications by authors named "Xue-Kun Xing"
Abortive transcript (AT) is a 2-19 nt long non-coding RNA that is produced in the abortive initiation stage. Abortive initiation was found to be closely related to RNA polymerase through experiments. Therefore, the distribution of AT length and the scale of abortive initiation are correlated to the promoter, discriminator, and transcription initiation sequence, and can be affected by transcription elongation factors.
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- Radiation-induced lung injury (RILI) is a major complication of radiation therapy, and researchers have found that long non-coding RNAs (lncRNAs) play a key role in its development.
- In a study using mouse models, researchers examined lung tissues after exposure to X-ray irradiation, identifying significant changes in the expression of mRNAs, miRNAs, and lncRNAs, which were mapped in a lncRNA-miRNA-mRNA ceRNA axis.
- The findings suggest key pathways and regulatory mechanisms involved in RILI, highlighting the importance of dysregulated gene expression, particularly the role of BNIP1 in promoting cellular apoptosis after radiation exposure.
Benzoylaconitine (BAC), the main hydrolysate of aconitine, is a lower toxic monoester type alkaloid considered as the pharmacodynamic constituent in Aconitum species. In this study, the effects and mechanisms of BAC on production of inflammatory cytokines interleukin (IL)-6 and IL-8 were investigated in IL-1β-stimulated human synovial SW982 cells. The SW982 cells were incubated with BAC (0, 5 and 10 µM) before stimulating with IL-1β (10 ng/mL).
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