Publications by authors named "Xue-Ke Zhang"

Article Synopsis
  • Cervical cancer (CC) affects women globally, and while extensive research has been conducted on its development at various biological levels, there has been limited focus on post-translational modifications (PTMs) in understanding CC progression.
  • This study compared PTM levels between normal cervical tissues and CC tissues, identifying that pan-acetylation was significantly decreased in cancer samples, while the acetylation of PARP1 at K119 was notably increased.
  • Overexpressing PARP1-WT reduced cancer cell proliferation and impacted specific signaling pathways, particularly decreasing p-ERK1/2 levels, indicating that the acetylation of PARP1 at K119 plays a crucial role in regulating the progression of cervical cancer.
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Sixteen alkaloid compounds were isolated from the dried rhizomes of , including a pair of new enantiomers (/)-7'-ethoxy--p-couma-royltyramine (/) and 14 known compounds (2-14) isolated from this plant for the first time. The structures of new compounds were identified by IR, NMR and MS spectroscopic analysis, and their absolute configurations were determined by comparison of the experimental and calculated ECD data.

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Accumulating evidence indicates that the glymphatic system has a critical role in maintaining brain homeostasis. However, the detailed anatomy of the glymphatic pathway is not well understood, mostly due to a lack of high spatial resolution 3D visualization. In this study, a fluorescence micro-optical sectioning tomography (fMOST) was used to characterize the glymphatic architecture in the mouse brain.

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The quantitative changes of anti-cancer ingredients such as taxol, cephalomannine, baccatin III and 10-deacetylbaccatin III in the branches and leaves of Taxus chinensis var. mairei during one growth season were measured by HPLC. The results showed that the contents of these anticancer ingredients had an obvious change from April when the new branches began to germinate to November when the branches basically stopped growing.

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