Role of Clinical Features, Pathogenic and Etiological Characteristics of Community-acquired Pneumonia with Type 2 Diabetes Mellitus in Early Diagnosis.

Objective: To study the etiological characteristics of community-acquired pneumonia (CAP) combined with type 2 diabetes (T2D), providing a reference for early clinical diagnosis and treatment of the disease.

Methods: We selected a total of 93 patients with CAP and analyzed their metagenomics nextgeneration sequencing (mNGS) data. The case group comprised 46 patients with combined CAP/T2D, and the control group comprised 47 patients without diabetes.

Clinical characteristics and pathogen analysis of bronchoalveolar lavage fluid in elderly patients with community-acquired pneumonia.

Objective: To analyze the clinical characteristics and bronchoalveolar lavage fluid pathogens in elderly patients with community-acquired pneumonia (CAP).

Methods: This was a retrospective observational epidemiological study using that elderly cases diagnosed with community-acquired pneumonia receiving treatment at the Affiliated Hospital of North China University of Technology, Tangshan Hongci Hospital and Tangshan Fengnan District Hospital of Traditional Chinese Medicine. A total of 92 cases were divided into two groups according to age.

The De Novo Genome Sequencing of Silver Pheasant (Lophura nycthemera).

Silver pheasant (Lophura nycthemera) belongs to Phasianidae, Galliformes, which exhibits high subspecific differentiation. In this study, we assembled a novel genome based on 98.42 Gb of Illumina sequencing data and 30.

The mitogenome of common snipe, Linnaeus, 1758 and evolutionary implications for the family Scolopacidae.

The mitochondrial genome (mitogenome) of Linnaeus, 1758 was determined by the high-throughput data. The assembled mitogenome was 16,919 bp in length, with a 58.7% A + T content and GC skew of -0.

The first mitogenome of Lesser Whitethroat, Ticehurst & Whistler, 1933 (Passeriformes: Sylviidae) and its phylogenetic implications for the genus .

The complete mitogenome of the Lesser Whitethroat, Ticehurst & Whistler, 1933 was determined, which belongs to Sylviidae, Passeriformes. The mitogenome had a length of 17,959 bp and consisted of 37 genes including 13 PCGs, 2 ribosomal RNAs (rRNA) genes, and 22 transfer RNAs (tRNA) genes. In addition, two control regions (CRs) were also existed in the mitogenome, with Sylvioidea typcial gene arrangement of cytb-trnT-CR1-trnP-nad6-trnE-CR2-trnF-rrnS.

Phragmunis a suppresses glioblastoma through the regulation of MCL1-FBXW7 by blocking ELK1-SRF complex-dependent transcription.

Glioblastoma (GBM) is a highly aggressive brain tumor. During screening work, we found a new compound named phragmunis A (PGA), which is derived from the fruitbody of Trogia venenata, exhibits a potential cytotoxic effect on patient-derived recurrent GBM cells and temozolomide (TMZ)-resistant cell lines. The present study was designed to investigate the potential molecular mechanism of the anti-glioma effects of PGA in vitro and in vivo.

Mitochondrial genome of captive Alpine musk deer, (Moschidae), and phylogenetic analyses with its coordinal species.

Alpine musk deer, , a solitary, primitive ungulate inhabiting high elevation areas (3000-4500 m) is an endangered species facing threat of extinction globally due to excessive hunting for its musk. In this study, we determined the complete mitochondrial genome of , which was 16,354 bp in length, and revealed the same gene order and genomic organization as typical Moschidae mitochondrial DNA. Start codons in 13 protein-coding genes (PCGs) were all typical ATGs except ATA for and and ATT for .

Characterization of the complete mitogenomes of Baillon's Crake and phylogenetic analysis.

The complete mitochondrial genome of the Baillon's Crake (Gruiformes: Rallidae) are sequenced and annotated, which contained 37 typical genes. The length of the complete mitochondrial genome is 16,966 bp (GenBank No. MW043485), with As, Ts, Cs, Gs, and AT content of the mitochondrial genome is 32.

Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.

We previously found that polydatin could attenuate renal oxidative stress in diabetic mice and improve renal fibrosis. Recent evidence shows that NADPH oxidase 4 (Nox4)-derived reactive oxygen species (ROS) contribute to inflammatory and fibrotic processes in diabetic kidneys. In this study we investigated whether polydatin attenuated renal fibrosis by regulating Nox4 in vitro and in vivo.

Complete mitochondrial genome of Golovatch, 2013 by next generation sequencing (Polydesmida: Paradoxosomatidae) and phylogenetic analysis in Diplopoda.

The mitogenome of was 15,623 bp long, revealed the same gene order to that of typical Polydesmida. Both the and lacked the DHU arms. No tandem repeat was found in two control regions.

Mitochondrial genomes of three Tetrigoidea species and phylogeny of Tetrigoidea.

The mitochondrial genomes (mitogenomes) of , and (Orthoptera: Caelifera: Tetrigoidea) were sequenced in this study, and almost the entire mitogenomes of these species were determined. The mitogenome sequences obtained for the three species were 15,180, 14,495 and 14,538 bp in length, respectively, and each sequence included 13 protein-coding genes (PCGs), partial sequences of rRNA genes (rRNAs), tRNA genes (tRNAs) and a A + T-rich region. The order and orientation of the gene arrangement pattern were identical to that of most Tetrigoidea species.

The mitogenomes of and (Charadriiformes, Sternidae) and their phylogenetic implications.

and are two sympatric breeding species. The mitogenomes of and are 16,748 bp and 16,707 bp in size. Both two mitogenomes reveal the same gene order and genomic organization to that of typical avian mtDNA.

Characterization of the mitogenomes for two sympatric breeding species in Recurvirostridae (Charadriiformes) and their phylogenetic implications.

Recurvirostridae is a family of Charadriiformes that displays an amazing amount of characterization at evolutionary level. The mitogenomes of and are 17,378 bp and 16,856 bp in size, respectively. Both two mitogenomes reveal the same gene order and genomic organization to that of typical avian mtDNA.

Data on taxonomic status and phylogenetic relationship of tits.

The data in this paper are related to the research article entitled "Taxonomic status and phylogenetic relationship of tits based on mitogenomes and nuclear segments" (X.J. Li et al.

Complete mitochondrial genome of (Galliformes: Phasianidae).

The complete mitochondrial genome (mitogenome) of , consisting of 16,693 bp, was determined and analyzed. It displayed as typical genome organization as other Galliformes mitogenomes: 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes and one control region. The phylogenetic relationships of 25 Phasianidae species and three Odontophoridae species as outgroup using maximum likelihood and Bayesian inference methods based on a concatenated dataset from mitogenomes were analyzed.

Predicting essential genes and synthetic lethality via influence propagation in signaling pathways of cancer cell fates.

A major goal of personalized anti-cancer therapy is to increase the drug effects while reducing the side effects as much as possible. A novel therapeutic strategy called synthetic lethality (SL) provides a great opportunity to achieve this goal. SL arises if mutations of both genes lead to cell death while mutation of either single gene does not.

Syn-lethality: an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies.

Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL interactions have been identified in yeast, only a few have been known in human.

Evolutionary inspirations for drug discovery.

Conceptual innovations are needed to address the challenge of 'more investments, fewer drugs' in the pharmaceutical industry. Since the publication of The Origin of Species by Charles Darwin 150 years ago, evolution has been a central concept in biology. In this article, we show that evolutionary concepts are also helpful to streamline the drug-discovery pipeline through facilitating the discovery of targets and drug candidates.

Chemoinformatics approaches for traditional Chinese medicine research and case application in anticancer drug discovery.

Traditional Chinese Medicine (TCM), which has been used for thousands of years to treat diseases, provides unique theoretical and practical methodologies for disease control. With the increasing accumulation of TCM data, it is imperative to study and analyze these resources with modern technologies and to elucidate the molecular mechanisms of TCM therapy. However, the philosophy, framework and technique of TCM are quite different from those of Western medicine, which causes complications when attempting to design modern drug treatments based on TCM.

Valproic acid as a promising agent to combat Alzheimer's disease.

Alzheimer's disease (AD) is one of the most threatening diseases to the elderly population at present. However, there is no yet efficient therapeutic method to AD. Recently, accumulating evidence indicates that valproic acid (VPA), a widely used mood stabilizer and antiepileptic drug, has neuroprotective potential relevant to AD.

Potential anti-dementia agents in traditional Chinese medicine.

Dementia is becoming one of the biggest threats to human health. However, there is no efficient therapeutic approach so far. Thus, traditional medicines, which have accumulated certain experience in the treatment of dementia, are attracting more and more attention.