Publications by authors named "Xue-Jing Kang"
Article Synopsis
- Ion channels play a critical role in peripheral sensitization associated with neuropathic pain, particularly focusing on Ca3.2 T-type calcium channels in damaged dorsal root ganglion neurons.
- A rat model with spared nerve injury revealed that Ca3.2 expression increased in damaged medium-sized neurons, while intact neurons showed no significant changes.
- Blocking Ca3.2 using antisense oligodeoxynucleotides helped alleviate mechanical allodynia, indicating the potential target of Ca3.2 channels in treating neuropathic pain following peripheral nerve injury.
Injuries to peripheral nerve fibers induce neuropathic pain. But the involvement of adjacent uninjured fibers to pain is not fully understood. The present study aims to investigate the possible contribution of Ca3.
View Article and Find Full Text PDFBackground: Despite high prevalence of anxiety accompanying with chronic pain, the mechanisms underlying pain-related anxiety are largely unknown. With its well-documented role in pain and emotion processing, the amygdala may act as a key player in pathogenesis of neuropathic pain-related anxiety. Pain-related plasticity and sensitization of CeA (central nucleus of the amygdala) neurons have been shown in several models of chronic pain.
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