Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication.

Ethnopharmacological Relevance: Viral pneumonia is the leading cause of death after SARS-CoV-2 infection. Despite effective at early stage, long-term treatment with glucocorticoids can lead to a variety of adverse effects and limited benefits. The Chinese traditional herb Pogostemonis Herba is the aerial part of Pogostemon Cablin (Blanco) Benth.

Postbiotics: emerging therapeutic approach in diabetic retinopathy.

Diabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients that poses a serious risk as it can cause substantial visual impairment and even vision loss. Due to the prolonged onset of DR, lengthy treatment duration, and limited therapeutic effectiveness, it is extremely important to find a new strategy for the treatment of DR. Postbiotic is an emerging dietary supplement which consists of the inactivate microbiota and its metabolites.

Postbiotics in colorectal cancer: intervention mechanisms and perspectives.

Colorectal cancer (CRC) is a common malignancy affecting the gastrointestinal tract worldwide. The etiology and progression of CRC are related to factors such as environmental influences, dietary structure, and genetic susceptibility. Intestinal microbiota can influence the integrity of the intestinal mucosal barrier and modulate intestinal immunity by secreting various metabolites.

Daqing formula ameliorated allergic asthma and airway dysbacteriosis in mice challenged with ovalbumin and ampicillin.

Ethnopharmacological Relevance: Asthma is a chronic airway inflammatory disease that can lead to several complications caused by bacterial infections. However, recurrent attacks of the disease require long-term use of antibiotics, resulting in lung dysbiosis and poor outcomes. Daqing Formula (DQF) is a well-known herbal medicine in Pharmacopoeia of China, which is widely used for various stimuli-induced lower respiratory diseases, including asthma, bronchitis, and pneumonia.

Rgl-exomiR-7972, a novel plant exosomal microRNA derived from fresh Rehmanniae Radix, ameliorated lipopolysaccharide-induced acute lung injury and gut dysbiosis.

Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel therapeutic tool for preventing human diseases. However, the number of well-verified plant ELNs remains limited. In this study, the microRNAs in ELNs derived from fresh Rehmanniae Radix, a well-known traditional Chinese herb for treating inflammatory and metabolic diseases, were determined by using microRNA sequencing to investigate the active components in the ELNs and the protection against lipopolysaccharide (LPS)-induced acute lung inflammation in vivo and in vitro.

Development of a UPLC-MS/MS method for the determination of active ingredients of Shuang Hu in rat blood and its application in pharmacokinetics.

A simple and sensitive method using in vivo microdialysis coupled with UPLC-MS/MS was established to evaluate the pharmacokinetics of Shuang Hu tincture (SHZTN). Xevo TQ-S was used to analyze the active ingredients of mesaconitine, hypaconitine, 4-hydroxycinnamic acid, ferulic acid and N-(2, 3-dimethyl phenyl)-2- aminobenzoic acid of SHZTN. Samples were prepared using a methanol precipitation method and the internal standards lannaconitine and p-hydroxybenzoic acid were added.

A Review on Phytochemicals of the Genus and Their Bioactive Studies.

The genus is a member of the Celastraceae family, of which several species have long been used in traditional medicine. Between 1976 and 2021, nearly 270 new compounds have been isolated and elucidated from the genus . Among these, maytansine and its homologues are extremely rare in nature.

[Effects of porcine acellular cartilaginous matrix on the proliferation and differentiation of human adipose-derived stromal cells].

Objective: This study aimed to evaluate the effects of porcine acellular cartilaginous matrix (pACM) on the proliferation and differentiation of human adipose-derived stromal cells (hADSCs).

Methods: pACM was prepared from porcine articular cartilage through decellularization treatment. hADSCs were isolated from human adipose tissues and cultured with different pACM concentrations.

Effects of ginsenoside Rb1 on spinal cord ischemia-reperfusion injury in rats.

Background: The aim of this study was to evaluate the effects of different doses of ginsenoside Rb1 (GRb1) pretreatment on spinal cord ischemia-reperfusion (SCII) in rats and explore the potential mechanisms about the expression of survivin protein after the intervention.

Methods: A total of 90 healthy adult Sprague-Dawley (SD) rats were randomly divided into six groups: sham-operated (n = 15), SCII model (n = 15), and GRb1-treated groups (n = 60). The GRb1-treated group was divided into four subgroups: 10 mg/kg, 20 mg/kg, 40 mg/kg, and 80 mg/kg (n = 15).

[Spatiotemporal dynamic simulation on aboveground carbon storage of bamboo forest and its influence factors in Zhejiang Province, China.].

Bamboo forests have an efficient carbon sequestration capacity and play an important role in responding to global climate change. However, the current estimation of bamboo carbon storage has some errors, leading to uncertainty in the spatiotemporal pattern of bamboo forest carbon storage. This study simulated aboveground carbon storage of Zhejiang Province, China, during 1984-2014 based on the combination of an improved BIOME-BGC (biogeochemical cycles) model and remote sensing data, with the accuracy being verified with forest resource inventory data.

[Retrieval of leaf area index of Phyllostachys praecox forest based on MODIS reflectance time series data.].

Based on the MODIS surface reflectance data, five vegetation indices, including norma-lized difference vegetation index (NDVI), simple ratio index (SR), Gitelson green index (GI), enhanced vegetation index (EVI) and soil adjusted vegetation index (SAVI) were constructed as remote sensing variables, coupled with the seven original spectral reflectance bands of MODIS. Stepwise regression and correlation analysis were used to select the variables, and the stepwise regression and Back Propagation (BP) neural network models were constructed based on the measured LAI to retrieve the LAI time series data of Phyllostachys praecox (Lei bamboo) forest during the period from January 2014 to March 2017. The retrieval results were compared with MOD15A2 LAI products during the same period.

Management of patellar fracture with titanium cable cerclage.

Early rehabilitation after surgery for patellar fracture is challenging. The purpose of this study was to evaluate the surgical outcome of titanium cable cerclage for patellar fracture in early functional activity.We reviewed a series of 24 patients treated at our hospital with titanium cable.

Aptamer-functionalized Fe O magnetic nanoparticles as a solid-phase extraction adsorbent for the selective extraction of berberine from Cortex phellodendri.

The extraction adsorbent was fabricated by immobilizing the highly specific recognition and binding of aptamer onto the surface of Fe O magnetic nanoparticles, which not only acted as recognition elements to recognize and capture the target molecule berberine from the extract of Cortex phellodendri, but also could favor the rapid separation and purification of the bound berberine by using an external magnet. The developed solid-phase extraction method in this work was useful for the selective extraction and determination of berberine in Cortex phellodendri extracts. Various conditions such as the amount of aptamer-functionalized Fe O magnetic nanoparticles, extraction time, temperature, pH value, Mg concentration, elution time and solvent were optimized for the solid-phase extraction of berberine.

Detection of Aβ oligomers based on magnetic-field-assisted separation of aptamer-functionalized FeO magnetic nanoparticles and BaYF:Yb,Er nanoparticles as upconversion fluorescence labels.

A sensitive and stable bioassay for the detection of Aβ oligomer (Aβo), a potentially promising candidate biomarker for Alzheimer's disease (AD) diagnosis, was developed using FeO magnetic nanoparticles (MNPs) as the recognition and concentration elements and BaYF:Yb,Er upconversion nanoparticles (UCNPs) as highly sensitive labels, conjugated with the Aβo aptamer (DNA1) and the complementary oligonucleotide of the Aβo aptamer (DNA2), respectively. The DNA1 hybridized with DNA2 to form the duplex structure on the surface of the MNPs/UCNPs nanocomposites probe. When the target Aβo was introduced, the aptamer DNA1 preferentially bound with Aβo and caused the dissociation of some complementary DNA2, liberating some UCNP-labeled complementary DNA2 and leading to a decreased upconversion fluorescent intensity on the surface of MNPs.

[Simulating of carbon fluxes in bamboo forest ecosystem using BEPS model based on the LAI assimilated with Dual Ensemble Kalman Filter].

LAI is one of the most important observation data in the research of carbon cycle of forest ecosystem, and it is also an important parameter to drive process-based ecosystem model. The Moso bamboo forest (MBF) and Lei bamboo forest (LBF) were selected as the study targets. Firstly, the MODIS LAI time series data during 2014-2015 was assimilated with Dual Ensemble Kalman Filter method.

A quantitative RT-PCR assay for rapid detection of Eurasian-lineage H10 subtype influenza A virus.

Unlabelled: [Image: see text]

Electronic Supplementary Material: Supplementary material is available for this article at 10.1007/s12250-016-3826-1 and is accessible for authorized users.

[Retrieval of leaf net photosynthetic rate of moso bamboo forests using hyperspectral remote sen-sing based on wavelet transform].

This study focused on retrieval of net photosynthetic rate (Pn) of moso bamboo forest based on analysis of wavelet transform on hyperspectral reflectance data of moso bamboo forest leaf. The result showed that the accuracy of Pn retrieved by the ideal high frequency wavelet vegetation index ( VI) was higher than that retrieved by low frequency wavelet VI and spectral VI. Normalized difference vegetation index of wavelet (NDVIw), simple ratio vegetation index of wavelet (SRw) and difference vegetation index of wavelet (Dw) constructed by the first layer of high frequency coefficient through wavelet decomposition had the highest relationship with Pn, with the R² of 0.

[Advances in Biomarkers of Mild Traumatic Brain Injury in Cerebrospinal Fluid and Blood].

Mild traumatic brain injury (MTBI) is defined as a mild brain trauma resulting in a short loss of consciousness and alteration of mental status. It may also occasionally develop persistent and progressive symptoms. It has been confirmed that MTBI causes changes of anatomic structures in central nervous system and biomarkers in the body fluid.

Synthesis and hypoglycemic activity of esterified-derivatives of mangiferin.

Aim: To synthesize three novel esterified-derivatives of mangiferin and evaluate their hypoglycemic activities.

Methods: Acetic, propionic, and butyric anhydride were reacted with mangiferin, respectively. The hypoglycemic activity of the derivatives was evaluated using a hyperglycemic mouse model induced by streptozotocin (STZ), and the islet cells were checked by biopsy inspection.

Comparative analysis of a highly variable region within the genomes of Spodoptera frugiperda ascovirus 1d (SfAV-1d) and SfAV-1a.

The recently discovered ascoviruses have a worldwide distribution. Here we report a new member of the family Ascoviridae, Spodoptera frugiperda ascovirus 1d (SfAV-1d) with a variable region in the genome. Restriction fragment length polymorphism, Southern hybridization and genome sequencing analyses confirmed that SfAV-1d and the earlier reported SfAV-1a are closely related but are not identical.