Publications by authors named "Xue-Hong Song"
Article Synopsis
- IL-12Rβ2 is a crucial receptor subunit for IL-12 and IL-35 that influences Th1 cell development and inflammatory responses, but its role in teleost fish is under-researched.
- Researchers cloned and studied the IL-12Rβ2 gene from grass carp, revealing a cDNA of 2875 bp that translates into a 741-amino acid protein with key structural features.
- The study also highlighted IL-12Rβ2's involvement in intestinal inflammation, showing its expression patterns aligned with immune responses during infections, suggesting it plays a regulatory role in fish inflammation.
Characterization of interleukin-1β as a proinflammatory cytokine in grass carp (Ctenopharyngodon idella).
Fish Shellfish Immunol
October 2015
Article Synopsis
- Interleukin-1β (IL-1β) in grass carp was analyzed, revealing a gene structure with seven exons, and it showed different expression levels in various tissues under normal and stimulated conditions.
- The study produced a recombinant form of grass carp IL-1β, which was confirmed to have specific immunological interactions and demonstrated proinflammatory effects in response to bacterial stimulation.
- Overall, the findings suggest that gcIL-1β plays a significant role in the inflammatory response in grass carp, with similar mechanisms seen in mammals, despite structural differences.
Article Synopsis
- Interleukin-8 (IL-8) is an important chemokine involved in immune regulation and inflammation, and this study focuses on a homologue found in the grass carp, known as gcIL-8.
- Sequence analysis revealed that gcIL-8 shares significant similarities with IL-8 proteins in other fish and forms a unique clade distinct from those in birds, mammals, and amphibians.
- The study also showed that gcIL-8 is expressed differently in various tissues and is significantly upregulated during Aeromonas hydrophila infection, demonstrating its role in inflammatory responses by attracting immune cells and promoting inflammation.
[Multicenter randomized, double-blind, placebo-controlled trial of prostaglandin E1 cream for female sexual arousal disorder].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2010
Objective: To investigate the efficacy and safety of alprostadil cream in management of female sexual arouse disorder (FSAD), and its appropriate dose for clinical prescription.
Methods: The volunteers were assigned randomly to four groups which received alprostadil cream in different dosage (500 μg, 700 μg and 900 μg) or placebo cream, respectively. The cream was applied to the clitoris and G-spot before coitus.
Article Synopsis
- The study aimed to assess the clinical significance of atypical squamous cells (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) by analyzing the results of colposcopic biopsies and other procedures on 800 patients diagnosed with these conditions.
- Results showed that among patients with ASCUS, 57.04% had chronic cervicitis, while in LSIL patients, 50.89% had LSIL, indicating a variety of conditions present beyond just neoplasia. Notably, 79.63% of colposcopy impressions matched the histological diagnoses, demonstrating its effectiveness.
- Conclusions indicate that ASCUS and LSIL encompass diverse biological changes, including