Enhancement of ergothioneine production by discovering and regulating its metabolic pathway in Cordyceps militaris.

Background: Cordyceps militaris is a traditional medicinal fungus contains a variety of functional ingredients and has been developed as an important mushroom food recently. Ergothioneine, one of the antioxidative compounds in C. militaris, is benefits on aging-related diseases and therefore became a novel functional food nutritive fortifier.

Nonalcoholic fatty liver disease impacts the control of the international normalized ratio in patients with atrial fibrillation.

Background: It is unclear whether the therapeutic effect of warfarin in patients with atrial fibrillation (AF) and normal liver function differs between those with and without nonalcoholic fatty liver disease (NAFLD). With this in mind, we aimed to evaluate the impact of NAFLD on the international normalized ratio (INR) control in warfarin-treated AF patients with normal liver function.

Methods: We enrolled 600 AF patients aged 28-94 (median 68) with normal liver function who were receiving daily warfarin therapy, 172 with NAFLD and 428 without.

Prolonged P-wave duration is associated with atrial fibrillation recurrence after radiofrequency catheter ablation: A systematic review and meta-analysis.

Background/objectives: A change in the P-wave duration (PWD) was made in patients with atrial fibrillation recurrence (AFR) after radiofrequency catheter ablation (RFCA). The correlation between the PWD and AFR and the potential utilization of a prolonged PWD in the prediction of AFR after RFCA remains unclear.

Methods: Studies of PWD in patients with or without AFR after RFCA, and studies concerned with the predictive effect of prolonged PWD on AFR after RFCA, were included.