Integrating the Z-scheme heterojunction and hot electrons injection into a plasmonic-based ZnInS/WO composite induced improved molecular oxygen activation for photocatalytic degradation and antibacterial performance.

The semiconductor-based photocatalysts with local surface plasmon resonance (LSPR) effect can extend light response to near-infrared region (NIR), as well as promote charge-carriers transfer, which provide a novel insight into designing light-driven photocatalyst with excellent photocatalytic performance. Here, we designed cost-effective wide-spectrum ZnInS/WO composite with enhanced photocatalytic performance based on a dual-channel charge transfer pathway. Benefiting from the synergistic effect of Z-scheme heterostructure and unique LSPR effect, the interfacial charge-carriers transfer rate and light-absorbing ability of ZnInS/WO were enhanced significantly under visible and NIR (vis-NIR) light irradiation.

Orf Virus Antagonizes p53-Mediated Antiviral Effects to Facilitate Viral Replication.

As a zoonotic disease, ovine contagious pustular dermatitis (Orf) is a serious threat to sheep as well as humans. Orf virus (ORFV) interferon resistance protein (VIR) is the principal virulence protein that encodes a dsRNA-binding protein to inhibit host antiviral response. p53 is one of the key proteins of the host antiviral innate immunity.

Systematic Profiling and Evaluation of Structure-based Kinase-Inhibitor Interactome in Cervical Cancer by Integrating In Silico Analyses and In Vitro Assays at Molecular and Cellular Levels.

Various protein kinases are implicated in the pathogenesis of human cervical cancer and many kinase inhibitors have been used to regulate the activity of protein kinases involved in the disease signaling networks. In the present study, a systematic kinase-inhibitor interactome is created for various small-molecule inhibitors across diverse cervical cancer-related kinases by using ontology enrichment, molecular docking, dynamics simulation and energetics analysis. The interactome profile is examined in detail with heatmap analysis and heuristic clustering to derive promising inhibitors that are highly potential to target the kinome of human cervical cancer in a multi-target manner.

Constructing magnetic and high-efficiency AgI/CuFeO photocatalysts for inactivation of Escherichia coli and Staphylococcus aureus under visible light: Inactivation performance and mechanism analysis.

Magnetic materials usually exhibit advanced performance in many areas for their easy separating and recycle ability. In this study, silver iodide/copper ferrite (AgI/CuFeO) catalysts with excellent magnetic property were successfully synthesized and characterized by a series of techniques. Two typical bacteria Escherichia coli (E.

Advancement in TPL2-regulated innate immune response.

Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-κB, and the differentiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response.

Construction of highly efficient and stable ternary AgBr/Ag/PbBiOBr Z-scheme photocatalyst under visible light irradiation: Performance and mechanism insight.

In this work, the novel ternary AgBr/Ag/PbBiOBr Z-scheme photocatalysts were synthesized via a CTAB-assisted calcination process. The AgBr/Ag/PbBiOBr composites were employed for the degradation of rhodamine B (RhB) and antibiotic bisphenol A (BPA) under visible light irradiation. Results showed that the obtained AgBr/Ag-3/PbBiOBr displayed optimal photocatalytic performance, which could remove almost all RhB within 25 min and effectively decompose 82.

Graphene sponge decorated with copper nanoparticles as a novel bactericidal filter for inactivation of Escherichia coli.

Nanotechnology has great potential in water purification. However, the limitations such as aggregation and toxicity of nanomaterials have blocked their practical application. In this work, a novel copper nanoparticles-decorated graphene sponge (Cu-GS) was synthesized using a facile hydrothermal method.

Clinicopathological significance of increased ZIC1 expression in human endometrial cancer.

Zinc finger of the cerebellum (ZIC1), one of ZIC family genes, has been shown to play important roles in many cancers such as gastric cancer and breast cancer. However, there is little known about the expression and significance of ZIC1 in endometrial cancer. The aim of this study was to determine the expression pattern and clinicopathological significance of ZIC1 in endometrial cancer.

Decolorization of an azo dye Orange G in microbial fuel cells using Fe(II)-EDTA catalyzed persulfate.

This study constructed a microbial fuel cell (MFC) using Fe(II)-EDTA catalyzed persulfate as the cathode solutions to decolorize Orange G (OG) and harvest electricity simultaneously. Chelated Fe(2+) could activate persulfate to generate sulfate free radicals (SO(4)(-)) which with high oxidation potential (E(0)=2.6 V) can degrade azo dyes.

Stimulation of bioluminescence in Noctiluca sp. using controlled temperature changes.

Bioluminescence induced by multifarious stimuli has long been observed and is remains under investigation because of its great complexity. In particular, the exact mechanism underlying bioluminescence is not yet fully understood. This work presents a new experimental method for studying Noctiluca sp.

Refolding and characterization of recombinant human GST-PD-1 fusion protein expressed in Escherichia coli.

Programmed death-1 (PD-1) is a costimulatory molecule of CD28 family expressed on activated T, B and myeloid cells. The engagement of PD-1 with its two ligands, PD-L1 and PD-L2, inhibits proliferation of T cell and production of a series of its cytokines. The blockade of PD-1 pathway is involved in antiviral and antitumoral immunity.