Protective Effects of Colivelin Against Alzheimer's Disease in a PDAPP Mouse Model.

Background: Alzheimer's disease (AD) is characterized with progressive memory loss and severe cognitive impairments, which affect everyday life and human health in the elderly. It is required that an effective and safe protective reagent against AD should be developed. It has been reported that humanin (HN) exerts neuroprotective effects against AD.

Neuropeptide Y Gene Promoter -399T/C Polymorphism Increases Risk of Ischemic Stroke.

Background: Several genetic factors underlying ischemic stroke have been identified. Variants of Neuropeptide Y (NPY), whose product plays diverse roles in modulating physiological functions, have been associated with an increased risk of ischemic stroke in South Korean individuals.

Aims: We explored the association between a polymorphism in the NPY gene promoter at position -399 and the risk of ischemic stroke in Han Chinese.

Hierarchical self-assembly of superlattice hybrids consisting of periodic and alternating cores of porphyrin molecules separated by nanoscale silica walls.

Molecularly engineered superlattice hybrids consisting of periodic and alternating cores of porphyrin molecules separated by nanoscale silica walls were synthesized through a one-step organic-inorganic hierarchical self-assembly approach. The self-assembly process not only could lock both porphyrin and inorganic building blocks into ordered 3D nanostructure but also could allow for the molecular-level controllable organization of porphyrin molecules in the central regions of the silica pore channels, which leads to the formation of porphyrin core-silica wall superlattice hybrids with molecular-scale and mesoscale ordering. It was demonstrated that both the mesostructure and morphology of the hybrids can be finely tailored by turning the cooperative self-assembly process.

Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure.

Objective: Excessive aluminum (Al) exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential linkage between chronic Al exposure and Alzheimer's disease. The present study aims to evaluate the effects of tetrahydroxy stilbene glucoside (TSG), the extract from herbal medicine Polygoni Multiflori, on cognitive impairment and the over-expression of hippocampal amyloid precursor protein (APP) induced by chronic exposure to Al in rats.