[Changes of schistosomiasis endemic situation and water body security in Changsha City section of Xiangjiang River].

Objective: To understand the changes of schistosomiasis endemic situation and water body security in the Changsha City section of the Xiangjiang River.

Methods: The prevention and control measures of schistosomiasis, the status of Oncomelania hupensis snails in the marshlands, and the schistosome infection rates of residents on the both sides of the river and boat fishermen were investigated from 2003 to 2012. The schistosome infectivity of the water body was investigate by the method of sentry mice.

[Effect of cultivation for snail control on schistosomiasis in Changsha urban section of Xiangjiang River].

Objective: To study a reliable, friendly environmental and sustainable Oncomelania snail control method in marshlands of the Xiangjiang River.

Methods: According to the special characteristics of the marshlands of the Xiangjiang River, smoothing and cultivating in beaches were applied for snail control. In sections with scarce distribution of snails, lowering parts of 4.

A new strategy for the synthesis of 1,4-benzodiazepine derivatives based on the tandem N-alkylation-ring opening-cyclization reactions of methyl 1-arylaziridine-2-carboxylates with N-[2-bromomethyl(phenyl)]trifluoroacetamides.

A new method for the synthesis of novel 1,4-benzodiazepine derivatives has been established from a one-pot reaction of methyl 1-arylaziridine-2-carboxylates with N-[2-bromomethyl(aryl)]trifluoroacetamides. The reaction proceeds through the N-benzylation and highly regioselective ring-opening reaction of aziridine by bromide anion followed by Et3N-mediated intramolecular nucleophilic displacement of the bromide by the amide nitrogen. The easy availability of starting materials, simple and convenient synthetic procedure, and formation of functionalized 1,4-benzodiazepine scaffold ready for further chemical manipulations render this strategy useful in synthetic and medicinal chemistry.