Publications by authors named "Xue-Fei Deng"
The colorectal neoplasia differentially expressed (CRNDE) gene encodes a long non-coding RNA (lncRNA) that is the most unregulated among 129 lncRNAs differentially expressed in gliomas. In this study, we confirmed high CRNDE expression in clinical glioma specimens and observed through experiments in human glioma cell lines a novel molecular mechanism by which CRNDE may contribute to glioma pathogenesis. By inducing or silencing CRNDE expression, we detected a positive correlation between CRNDE levels and the proliferative, migratory, and invasive capacities of glioma cells, which were concomitant with a decreased apoptosis rate.
View Article and Find Full Text PDFHypertrophic scar (HS) is a pathological scar that particularly occurs after traumatic injuries, surgical procedures and burning. Abnormal activation of hypertrophic scar fibroblasts (HSFs) intensifies fibrosis during wound healing. Our previous studies demonstrated that recombinant human endostatin (rhEndostatin) prevented synovial thickening in adjuvant arthritis (AA) rats via inhibition of proliferation and enhancement of apoptosis in synovial fibroblasts.
View Article and Find Full Text PDFRheumatoid arthritis (RA) is characterized by pronounced synovial hyperplasia resulting in pannus formation, cartilage erosion and ultimately joint destruction. Activated RA synovial fibroblasts (SFs) mediate the invasion and destruction of cartilage and bone. We previously demonstrated that recombinant human endostatin (rhEndostatin) is sufficient to induce SF apoptosis in adjuvant arthritis (AA) rats.
View Article and Find Full Text PDF[Anatomical observation of the 'holy plane' for total mesorectal excision].
Zhonghua Wei Chang Wai Ke Za Zhi
January 2011
Article Synopsis
- The study aimed to identify the "holy plane," an important anatomical layer in total mesorectal excision, which exists between the fascia propria and adjacent fascia.
- The research involved examining 26 adult male pelvic specimens, revealing that the rectovesical septum and other layers showed no significant blood vessels or nerves in most cases, although some variations were noted.
- Findings concluded that the "holy plane" is located between the fascia propria and surrounding fascia, providing crucial anatomical insight for surgical procedures in the pelvic area.
Purpose: Although arachnoid granulations (AGs) were initially described by Pacchioni more than 300 years ago, they are still poorly described, especially those in middle cranial fossa. The aim of this study was to identify anatomical features of AGs in middle cranial fossa of cadaver and compare such features with that of 64-slice computed tomography.
Methods: The study involved anatomical dissection of 33 adult cadaveric heads and computed tomographic (CT) examinations of 40 patients with various intracranial diseases.