Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.

Background: Histone modifications are critical in regulating neuronal processes. However, the impacts of individual histone modifications on learning and memory are elusive. Here, we investigated the contributions of histone H3 lysine modifications to learning and memory in Drosophila by using histone lysine-to-alanine mutants.