Publications by authors named "Xue-Dong Sun"

Purpose: To assess the long-term outcome of performing uterine artery embolization (UAE) using small particles in women with symptomatic adenomyosis (AD).

Methods: Twenty-seven consecutive women (median age 42 years, range 29-53 years) with AD, in eight cases AD combined with fibroids, who underwent UAE between February 2015 and January 2019, were retrospectively analyzed. The embolization was performed using small-sized polyvinyl alcohol particles (100 μm and 300 μm).

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  • * Researchers analyzed data from various studies, focusing on metrics such as overall survival, progression-free survival, response rates, and side effects, using a systematic review approach and statistical models.
  • * Findings indicate that while COX-2 inhibitors did not improve overall survival or other key survival metrics, there was a better overall response rate in some cases, although they also led to increased severe side effects like blood toxicity and cardiovascular issues.
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Background: Total knee arthroplasty (TKA) is a surgical procedure to replace the weight-bearing surfaces of the knee joint to relieve pain and disability. However, blood loss and fibrinolytic activity, accounting for a poor prognosis following TKA operation, were relieved by fibrinolytic inhibitor tranexamic acid (TXA). For a better application of TXA function, we explored the effect of intravenous injection (IV) of TXA combined with intra-articular injection (IA) of TXA in patients after TKA.

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Osteoarthritis (OA) is the third most common diagnosis made by general practitioners in older patients. The purpose of the current study is to investigate effects rivaroxaban had on both hidden blood loss and blood transfusion rate (BTR) in patients with knee OA (KOA) after going through a total knee replacement (TKR).Between the time periods of December 2011 up until January 2015, a total of 235 patients underwent TKR and were selected to be assigned to either the rivaroxaban or nonanticoagulant groups.

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As one of the most important decorative materials for the modern household products, decorative papers impregnated with melamine not only have better decorative performance, but also could greatly improve the surface properties of materials. However, the appearance quality (such as color-difference evaluation and control) of decorative papers, as an important index for the surface quality of decorative paper, has been a puzzle for manufacturers and consumers. Nowadays, human eye is used to discriminate whether there exist color difference in the factory, which is not only of low efficiency but also prone to bring subjective error.

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[Research advances on microchimerism].

Zhongguo Shi Yan Xue Ye Xue Za Zhi

August 2014

The microchimerism is a status of the microcell or DNA of an individual in another one with genetic differences. Taking an overall view about the discovery and research of the microchimerism, it was found that although the study of the microchimerism emphasizes the formation, origin, distribution, type, relationship to disease and several other aspects, the objects of the study are always the microchimerism that obtained naturally. As it is known to all, the microchimerism can also be produced in some clinical treatment, such as in the transplant and transfusion, but compared with the microchimerism gained naturally, obviously, the study for the iatrogenic microchimerism formed in the treatment is not elaborate enough.

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This study was purposed to establish and identify a H-2 completely mismatched microtransplantation model of leukemia mouse. The recipients were female BALB/c mice, while donors were male C57BL/6J mice. Recipients were inoculated intravenously with 1×10(6) of WEHI-3 cells, a cell line of myelomonocytic leukemia.

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Purpose: Despite best current therapies, approximately half of patients with acute myeloid leukemia in first complete remission (AML-CR1) with no HLA-identical donors experience relapse. Whether HLA-mismatched stem-cell microtransplantation as a novel postremission therapy in these patients will improve survival and avoid graft-versus-host disease (GVHD) is still unknown.

Patients And Methods: One hundred one patients with AML-CR1 (9 to 65 years old) from four treatment centers received programmed infusions of G-CSF-mobilized HLA-mismatched donor peripheral-blood stem cells after each of three cycles of high-dose cytarabine conditioning without GVHD prophylaxis.

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This study was aimed to investigate the effect of recombinant human granulocyte colony-stimulating factor(G-CSF) on murine thymocyte emigration and cell cycle alteration after a sublethal dose of gamma-irradiation. Female BALB/c mice were given 6.0 Gy γ-ray total body irradiation and then randomly divided into G-CSF and control groups.

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This study was aimed to investigate the expression level of NOV and BNIP3 mRNA in mice myelomonocytic leukemia (AML-M(4)) and its significance. The mice were inoculated intravenously with myelomonocytic leukemia cells of WEHI-3, and divided randomly into chemotherapy group and control (untreated) group. Bone marrow samples were then collected from both groups at different times.

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Article Synopsis
  • The study investigates how specific T-cell subsets induced by the WT1 protein relate to the development of graft-versus-host disease (GVHD) after a type of stem cell transplant (NST).
  • Out of 19 patients, 17 experienced GVHD, with specific T-cell types (Tc1 and Th1) peaking at the onset of the disease, indicating a connection between these cells and GVHD severity.
  • Results suggest that the presence of Th1 cells is particularly significant in patients with extensive chronic GVHD, highlighting their potential role in enhancing the immune response against graft-versus-leukemia (GVL) effects during transplant recovery.
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Treatment outcome of acute myeloid leukemia (AML) in elderly patients remains unsatisfactory. It has been shown that the infusion of granulocyte colony-stimulating factor-mobilized donor peripheral blood stem cells (G-PBSCs) can enhance graft-versus-leukemia effects and speed hematopoietic recovery. Fifty-eight AML patients aged 60-88 years were randomly assigned to receive induction chemotherapy with cytarabine and mitoxantrone (control group; n = 28) or it plus human leukocyte antigen-mismatched G-PBSCs (G-PBSC group; n = 30).

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  • - The study aimed to assess the effectiveness of using a combination of pentamer and intracellular IFNgamma staining for detecting T cells that are specific to the WT1 antigen in patients suffering from leukemia.
  • - It was found that while WT1 expression was low in only 2 out of 14 matched donors, varying levels of WT1 expression appeared in all leukemic patients, with T cells detectable in some patients both before and after transplantation.
  • - After transplantation, the detection rates of WT1+CD8+ CTL and WT1+IFNgamma+ cells significantly increased, with higher levels of IFNgamma+ cells observed, indicating that this combination method allows for more accurate identification of antigen-specific T cells in these patients
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  • Clinical studies indicate that NST is more effective for treating chronic myelogenous leukemia (CML) compared to acute leukemia (AL), but the differences in graft-versus-leukemia (GVL) effects early after NST have not been thoroughly investigated.
  • Using a special staining technique, researchers found that the timing of certain immune cells (WT1(+)CD8(+)CTL/WT1(+)Tc1) emerging post-NST was similar in both AL and CML patients, although the WT1(+)Th1 cells appeared faster in AL patients.
  • Overall, the proportions and levels of WT1-specific T cells were comparable between AL and CML patients after treatment, suggesting that the GVL effects induced by WT
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