Publications by authors named "Xue-Cheng Wang"

Since ancient times, traditional Chinese medicine pills have occupied a key position among different dosage forms of traditional Chinese medicine. With the aims of comprehensively improving the overall quality and innovating key technologies in the manufacturing of the pills, this article elaborates on the principles and new technology applications in pulverizing, sterilization, agglomeration, forming, and drying. In addition, modern technologies such as biosensing, image analysis, texture property evaluation, and moisture analysis can comprehensively and accurately characterize the quality of key materials in the manufacturing of traditional Chinese medicine pills, thereby achieving strict control over the quality of raw materials, intermediates, and final products and further monitoring and optimizing the entire production process of pill preparations.

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Article Synopsis
  • * Solid preparations, the primary form of TCM drugs, require complex manufacturing processes and strict quality control, leading enterprises to revamp their methods for better quality and efficiency.
  • * This paper reviews recent policies and studies on TCM manufacturing, discussing the challenges and trends in intelligent manufacturing, aiming to support future research and development in the field.
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  • The safety of patients using traditional Chinese medicine depends on the quality of the preparations they receive.
  • The article talks about problems in how these medicines are made and the important tools used in the process.
  • It suggests a system to evaluate the quality of these medicines to help improve their safety and effectiveness.
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Drying is an indispensable processing step for Chinese medicinal materials after harvesting. It often leads to significant changes in the active components of these materials, thus impacting their medicinal values. Understanding the mechanisms behind the changes during the drying process is of great importance for regulating the transformation of key active components.

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  • Spray drying is a popular method used to make traditional Chinese medicine (TCM) because it dries quickly and keeps the product quality uniform.
  • However, TCM extracts can be tricky to work with, causing problems like sticking to surfaces and clumping together during the spray drying process.
  • Researchers are now using a new technique that studies the drying of single droplets to better understand and improve the spray drying method for TCM, which could lead to faster and more effective production.
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In recent years, continuous manufacturing technology has attracted considerable attention in the pharmaceutical industry. This technology is highly sought after for its significant advantages in cost reduction, increased efficiency, and improved productivity, making it a growing trend in the future of the pharmaceutical industry. Compared to traditional batch production methods, continuous manufacturing technology features real-time control and environmentally friendly intelligence, enabling pharmaceutical companies to produce drugs more efficiently.

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  • * The paper reviews various drying methods, discusses the current state of numerical simulation in drying, and highlights modeling techniques and software that can help streamline R&D and improve drying equipment and processes.
  • * Despite its advantages, the paper identifies issues with numerical simulation in drying, such as low accuracy and insufficient research on drug quality changes, while also suggesting future applications and directions for further study in TCM drying.
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As one of the most important applications of digitalization, intelligence, and service, the digital twin (DT) breaks through the constraints of time, space, cost, and security on physical entities, expands and optimizes the relevant functions of physical entities, and enhances their application value. This phenomenon has been widely studied in academia and industry. In this study, the concept and definition of DT, as utilized by scholars and researchers in various fields of industry, are summarized.

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Objectives: Gap junction protein alpha 5 (GJA5), also termed connexin 40 (Cx40), exerts a pivotal role in the mediation of vascular wall tone and two closely-linked polymorphisms in the promoter (-44G>A and +71A>G) have been associated with enhanced susceptibility to essential hypertension (EH) in men. The present investigation aimed to ascertain whether a novel common polymorphism within the upstream regulatory region of (transcript 1B), -26A>G (rs10465885), confers an increased risk of EH.

Methods: For this investigation, 380 unrelated patients with EH and 396 unrelated normotensive individuals employed as control persons were enrolled from the Chinese Han-ethnicity population, and their genotypes and plasma renin concentrations were determined by Sanger sequencing and an automated chemiluminescent immunoassay, respectively.

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  • - The study investigated the effectiveness of a new spiral vibration drying technology on various Chinese medicinal pills and compared it to traditional methods like hot air and vacuum drying.
  • - Results showed that the spiral vibration drying significantly reduced the drying time to 80 minutes, saving about 10%-13% in energy consumption, and improved the uniformity and quality of the drying process.
  • - This innovation is believed to enhance the drying efficiency and manufacturing capacity of Chinese medicinal pills, potentially influencing future developments in medicinal product drying technologies.
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Since leaves are rich in bioactive constitutes, particularly volatile compounds, there are higher demands for high-quality dried medicinal and aromatic peppermint products. This study aimed to assess the drying kinetics of hot air thin layer drying leaves and exploring the effects of hot air-drying temperatures on the textural properties and sensory quality. According to our results, the Midilli model is the best model representing the hot air-drying process.

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Due to the characteristics of confusing varieties of Chinese medicinal materials, different sources, complex chemical composition, non-standard preparation process, and non-standard pharmaceutical equipment, the quality of Chinese medicinal preparations is difficult to be controlled and evaluated effectively under the current quality control mode and method of Chinese medicinal preparation. The present study proposed an engineering quality view of Chinese medicine pharmacy and a strategy to control the quality of Chinese medicinal preparations based on the current situation. The "overall, dialectical, and dynamic" multi-factor engineering quality view, covering original medicinal materials, preparation technologies, pharmaceutical equipment, and Chinese medicinal preparations, ensures the traceable process, measurable procedures, and feedback quality.

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Drying is one of the most common unit operations in the production of traditional Chinese medicine. The drying process of traditional Chinese medicine materials is accompanied by the dynamic reduction of water content. As a key index to determine the end of the drying process, the moisture content of materials plays an important role in improving drying efficiency and saving energy.

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  • Dry granulation technology streamlines the granulation process by minimizing intermediate steps and costs, relying heavily on material characteristics and specialized equipment.
  • Despite its success in various industries like food and chemicals, research on applying this technology to traditional Chinese medicine remains underdeveloped.
  • The advantages of dry granulation in traditional Chinese medicine include a simplified process that maintains quality, producing granules that are crucial for the manufacturing of solid preparations and ultimately affect the product's quality.
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  • Innovative infrared-steam blanching (ISB) was found to effectively inactivate peroxidase (POD) in L. flowers with better retention of phenolics, carotenoids, and flavonoids compared to traditional steam blanching (SB) and infrared blanching (IB).
  • The study revealed that ISB allowed lower POD activity levels and produced brighter color in the flowers while preventing regeneration of POD during storage.
  • Overall, ISB for 90 seconds at 100°C is recommended as an effective blanching method for preserving the quality of natural plant products.
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  • * This paper looks at why the quality of TCM is so uneven by checking out research on how to control the quality of Chinese herbal products.
  • * The author suggests some ways to improve quality, like making sure herbs are grown and processed the same way and using better equipment, to help make TCM safer and more reliable.
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Product quality relies on not only testing methods,but also the design and development, production control and product manufacturing all aspects of logistics management. Quality comes from the process control level.Therefore, it is very important to accurately identify the factors that may induce quality risk in the production process and quality control measures correspondingly.

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Process design grants the quality connotation to products. This paper was to investigate the correlation between changes of chemical fingerprints of Andrographis Herba preparation and its pharmacological activity, and set up the bridge between key process and quality attributes. By referring to the preparation process of Andrographis Herba.

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The dry quality of traditional Chinese medicine pills is the hot spot of pills research, because their quality has a crucial effect on the efficacy and development of dosage forms. Through literature research and statistical analysis, we would review the current problems on the drying of traditional Chinese medicine pills in this paper, and surrounding the evaluation system for traditional Chinese medicine pills, analyze the characteristics of common drying equipment and processes as well as their effect on quality of pills, discuss the problems in drying equipment and process as well as quality, and put forward the corresponding strategies, hoping to provide new ideas and new methods for the quality improvement of traditional Chinese medicine pills and quality standards.

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Drying is the critical link during pharmaceutical process of traditional Chinese medicine (TCM), which is directly related to the quality of drugs. The key to technology upgrading of pharmaceutical equipment in Chinese materia medica enterprise is the development of new drying techniques, which concerns the modernization of TCM. The study provides new ideas for the drying technology and equipment by means of reviewing the research status of drying process for the traditional Chinese medicinal materials and preparations, and analyzing the traditional and modern drying methods and equipment, as well as their existing problems and corresponding measures for the drying processes and equipment.

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