Association between lipoprotein-associated phospholipase A and lower extremity arterial disease in type 2 diabetes mellitus.

Background: Lipoprotein-associated phospholipase A (Lp-PLA) is closely related to the development of cardiovascular diseases, and the association between Lp-PLA and lower extremity arterial disease (LEAD) in type 2 diabetes mellitus (T2DM) is inconsistent among previous studies. Thus, the present study aimed to investigate whether the increase in Lp-PLA is related to the occurrence of LEAD in patients with T2DM.

Methods: A total of 519 patients with T2DM (173 patients with LEAD and 346 patients without LEAD) were enrolled in this study.